There are a sufficient number of works devoted to modeling crushing machines. Nevertheless, the fact that there are a large number of working conditions, and the ongoing development of science and technology, require continuous improvement and specification of the models intended for crushing processes and those of the devices concerned. However, there are few studies related to single-roll gyratory crushers. Such crushers are promising for use in mines to crush rocks laid in the developed space. Mathematical modeling and optimization of the design parameters of the working chamber and the executive body (roll) of a single-roll gyratory shaft crusher, designed for crushing strong rocks, was performed in this paper. A differential equation was derived. As a result of its solution, the rational shape of the working chamber cheek of the single-roll gyratory crusher was established, representing a logarithmic spiral arc. Analytical expressions were derived to determine the rational rotation speed and productivity of the crusher under consideration. Expressions for calculating the kinematic load components acting on the roll were formulated. They are the periodic functions of the shaft rotation angle. The Fourier series expansion showed that the loads contained harmonics of the first, second, third and fourth orders. Using the concept of fuzzy sets, a multi-criteria optimization of the design parameters of the working chamber was performed, including the values of the eccentricity and the central angle of the beginning of the cheek profile. The variation coefficients of the kinematic components of the loads acting on the working body reduced, due to the optimal choice of the working chamber profile and the angular coordinates of the installation of the fixed cheeks. The torque reduced 1.67 times, while the radial load decreased 1.2 times.