Automated quality assurance routines for fMRI data applied to a multicenter study

Stöcker, Tony; Schneider, Frank; Klein, Martina I.; Habel, Ute; Kellermann, Thilo; Zilles, Karl; Shah, N. Jon

doi:10.1002/hbm.20096

Cited by 109 publications

(90 citation statements)

References 20 publications

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“…Realignment parameters (x, y, z, pitch, roll, and yaw) and 'percent signal change'Fan index of data variability and quality control (Stöcker et al, 2005)Fwere added as covariates. The resulting intrasubject contrast images entered random effects group analysis by means of repeated-measures ANOVA (mixed design) with the withinsubject factor 'emotion' and the between-subject factor 'group'.…”

Section: Data Acquisitionmentioning

confidence: 99%

Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

Seiferth

Pauly

Kellermann

et al. 2008

Neuropsychopharmacol

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Emotion discrimination deficits represent a well-established finding in schizophrenia. Although imaging studies addressed the cerebral dysfunctions underlying emotion perception in adult patients, the question of trait vs state characteristics is still unresolved. The investigation of juvenile patients offers the advantage of studying schizophrenia at an age where influences of illness course and long-term medication are minimized. This may enable a more detailed characterization of emotion discrimination impairments and their cerebral correlates with respect to their appearance and exact nature. A total of 12 juvenile patients with early onset schizophrenia and matched healthy juveniles participated in this study. fMRI data were acquired during an emotion discrimination task consisting of standardized photographs of faces displaying happy, sad, angry, fearful, or neutral facial expression. Similar to findings in adult patients, juvenile patients exhibited reduced performance specificity whereas sensitivity was unaffected. Independent of the valence, their processing of emotional faces was associated with hypoactivations in both fusiform gyri and in the left inferior occipital gyrus. In addition, hyperactivations in patients were found in the right cuneus common to happy, angry, and fearful faces. Further, most distinct changes were present in juvenile patients when processing sad faces. These results point to a dysfunction in cerebral circuits relevant for emotion processing already prominent in adolescent schizophrenia patients. Regions affected by a decrease in activation are related to visual and face processing, similar to deficits reported in adult patients. These changes are accompanied by hyperactivations in areas related to emotion regulation and attribution, possibly reflecting compensatory mechanisms.

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Section: Data Acquisitionmentioning

confidence: 99%

Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

Seiferth

Pauly

Kellermann

et al. 2008

Neuropsychopharmacol

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“…Of the 72 data sets, 11 were discarded due to intense head movements (n = 2: movement of more than twice the voxel size along the z axis and pitching the head > 3°; n = 1: pitching the head > 3°) or intense artifacts in the MRI raw data (n = 1) or because they did not meet the joint multicenter quality criteria (n = 6: > 2.5 SDs) on the point spread function [44] or signal-to-fluctuation noise ratio (SFNR) [45]. One patient dropped out during CBT treat- Values are presented as mean ± SD unless specified otherwise.…”

Section: Data Inclusionmentioning

confidence: 99%

Effects of Cognitive Behavioral Therapy on Neural Processing of Agoraphobia-Specific Stimuli in Panic Disorder and Agoraphobia

Wittmann¹,

Schlagenhauf²,

Guhn³

et al. 2018

Psychother Psychosom

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Background: Patients suffering from panic disorder and agoraphobia are significantly impaired in daily life due to anxiety about getting into a situation due to apprehension about experiencing a panic attack, especially if escape may be difficult. Dysfunctional beliefs and behavior can be changed with cognitive behavioral therapy; however, the neurobiological effects of such an intervention on the anticipation and observation of agoraphobia-specific stimuli are unknown. Methods: We compared changes in neural activation by measuring the blood oxygen level-dependent signal of 51 patients and 51 healthy controls between scans before and those after treatment (group by time interaction) during anticipation and observation of agoraphobia-specific compared to neutral pictures using 3-T fMRI. Results: A significant group by time interaction was observed in the ventral striatum during anticipation and in the right amygdala during observation of agoraphobia-specific pictures; the patients displayed a decrease in ventral striatal activation during anticipation from pre- to posttreatment scans, which correlated with clinical improvement measured with the Mobility Inventory. During observation, the patients displayed decreased activation in the amygdala. These activational changes were not observed in the matched healthy controls. Conclusions: For the first time, neural effects of cognitive behavioral therapy were shown in patients suffering from panic disorder and agoraphobia using disorder-specific stimuli. The decrease in activation in the ventral striatum indicates that cognitive behavioral therapy modifies anticipatory anxiety and may ameliorate abnormally heightened salience attribution to expected threatening stimuli. The decreased amygdala activation in response to agoraphobia-specific stimuli indicates that cognitive behavioral therapy can alter the basal processing of agoraphobia-specific stimuli in a core region of the fear network.

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“…Thus, data from all centers have been iteratively smoothed until a smoothness of 12-mm full width at half maximum was reached, independently of scanner-specific intrinsic smoothness of the data. Finally, the data quality [55,56] of the acquired data was carefully checked to avoid systematic differences between the patient and control groups [1]. …”

Section: Methodsmentioning

confidence: 99%

Neural Correlates of Procedural Variants in Cognitive-Behavioral Therapy: A Randomized, Controlled Multicenter fMRI Study

Straube¹,

Lueken²,

Jansen³

et al. 2014

Psychother Psychosom

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Background: Cognitive behavioral therapy (CBT) is an effective treatment for panic disorder with agoraphobia (PD/AG). It is unknown, how variants of CBT differentially modulate brain networks involved in PD/AG. This study was aimed to evaluate the effects of therapist-guided (T+) versus self-guided (T-) exposure on the neural correlates of fear conditioning in PD/AG. Method: In a randomized, controlled multicenter clinical trial in medication-free patients with PD/AG who were treated with 12 sessions of manualized CBT, functional magnetic resonance imaging (fMRI) was used during fear conditioning before (t1) and after CBT (t2). Quality-controlled fMRI data from 42 patients and 42 healthy subjects (HS) were obtained. Patients were randomized to two variants of CBT (T+, n = 22, and T-, n = 20). Results: The interaction of diagnosis (PD/AG, HS), treatment group (T+, T-), time point (t1, t2) and stimulus type (conditioned stimulus: yes, no) revealed activation in the left hippocampus and the occipitotemporal cortex. The T+ group demonstrated increased activation of the hippocampus at t2 (t2 > t1), which was positively correlated with treatment outcome, and a decreased connectivity between the left inferior frontal gyrus and the left hippocampus across time (t1 > t2). Conclusion: After T+ exposure, contingency-encoding processes related to the posterior hippocampus are augmented and more decoupled from processes of the left inferior frontal gyrus, previously shown to be dysfunctionally activated in PD/AG. Linking single procedural variants to neural substrates offers the potential to inform about the optimization of targeted psychotherapeutic interventions.

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Automated quality assurance routines for fMRI data applied to a multicenter study

Cited by 109 publications

References 20 publications

Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

Neuronal Correlates of Facial Emotion Discrimination in Early Onset Schizophrenia

Effects of Cognitive Behavioral Therapy on Neural Processing of Agoraphobia-Specific Stimuli in Panic Disorder and Agoraphobia

Neural Correlates of Procedural Variants in Cognitive-Behavioral Therapy: A Randomized, Controlled Multicenter fMRI Study

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