The Momentum program launched in 2009 provides funding of up to 1 million Euro to establish new, independent research groups at Hungarian academic institutions. Here, our aim was to determine factors associated with the scientific output of these research groups. Publication data were downloaded from the Hungarian Scientific Work Archive (www.mtmt.hu), impact factor data were obtained from Thomson Reuters (jcr.incites.thomsonreuters.com), and journal ranks were extracted from the Scimago Journal Rank database (www.scimagojr.com). Investigated input features for each grant holder include gender, degree, targeted category, international mobility, international grants, number of publications, total number of citations, H-index, best publications, impact factors in the last 2 years, and assessment scores provided by the experts. Evaluated performance indicators include cumulative impact factor, number of D1 publications, and number of first/last author D1 publications during the grant running time. Grant holders’ publication output increased by 23 and 52% for life sciences and material sciences researchers. Scientific performance was independent from gender, degree, international grants, category applied for, and citations received for the best pre-grant publication. Those with international mobility had significantly lower scientific output (yearly impact factor, number of D1 publications, number of first/last author publications). Scores received from grant review experts were independent from later publication activity. The strongest correlations were observed between scientific output and total number of citations, H-index, and impact factor in the last 2 years pre-grant. In summary, group leaders with a dynamic publication track record were able to attain the most additional momentum. Our results can help accelerate and improve future grant review processes.