Automated segmentation and spatial registration of white matter lesions in MR FLAIR images

Trebbe, O; Schwindt, Wolfram; Mohammadi, Shahed; Wersching, H.; Deppe, Martin H.

doi:10.1016/s1053-8119(09)70709-8

Cited by 1 publication

(1 citation statement)

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“…The FLAIR images were normalized into the gray matter DARTEL space by co-registering the original FLAIR and T1 scans using the SPM5 mutual information function and then applying the DARTEL normalization parameters to the FLAIR images. WMH were defined as clusters of at least two adjacent voxels across two image sections that had at least a 30% increase in signal intensity relative to the mean of the white matter signal (Trebbe et al, 2009 ) within the 50% probability DARTEL white matter template. The intra- and inter-rater reliability for the volume of labeled WMH was Cronbach's α = 0.93 and 0.90, respectively.…”

Section: Methodsmentioning

confidence: 99%

Age-related changes in processing speed: unique contributions of cerebellar and prefrontal cortex

Eckert

Keren

Roberts

et al. 2010

Front. Hum. Neurosci.

137

143

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Age-related declines in processing speed are hypothesized to underlie the widespread changes in cognition experienced by older adults. We used a structural covariance approach to identify putative neural networks that underlie age-related structural changes associated with processing speed for 42 adults ranging in age from 19 to 79 years. To characterize a potential mechanism by which age-related gray matter changes lead to slower processing speed, we examined the extent to which cerebral small vessel disease influenced the association between age-related gray matter changes and processing speed. A frontal pattern of gray matter and white matter variation that was related to cerebral small vessel disease, as well as a cerebellar pattern of gray matter and white matter variation were uniquely related to age-related declines in processing speed. These results demonstrate that at least two distinct factors affect age-related changes in processing speed, which might be slowed by mitigating cerebral small vessel disease and factors affecting declines in cerebellar morphology.

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Section: Methodsmentioning

confidence: 99%