Automated treatment planning for liver cancer stereotactic body radiotherapy

He, Ling; Peng, Xingchen; Chen, Na; Wei, Zhimei; Wang, Jingjing; Liu, Yingtong; Xiao, Jianghong

doi:10.1007/s12094-023-03196-4

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…An automatic SBRT planning program for liver SBRT was developed in‐house based on previous work. 18 , 19 This was used to simulate the manual plan designing process, which included creating the planning auxiliary structures, adding plan objectives and constraints, optimizing, and adjusting parameters during the whole optimization process. The minimum precision level of automatic adjustment (2 cGy) was much more precise than that of manual adjustment (often more than 50 cGy).…”

Section: Methodsmentioning

confidence: 99%

Optimization of collimator angle combined island blocking with parked gap achieves superior normal tissue sparing in SBRT planning of multiple liver lesions

Abuduxiku,

Chen,

Zhang

et al. 2024

J Applied Clin Med Phys

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PurposeTo propose an efficient collimator angle optimization method by combining island blocking (IB) and parked gap (PG) problem to reduce the radiotherapy dose for normal tissue. The reduction will be done with single‐isocenter multi‐lesion volumetric modulated arc therapy (VMAT) for the stereotactic body radiation therapy (SBRT) of liver cancer.MethodsA novel collimator angle optimization algorithm was developed based on the two‐dimensional projection of targets on a beam's eye view (BEV) plane as a function of gantry and collimator angle. This optimization algorithm minimized the sum of the combined IB and PG (IB & PG) areas from all gantry angles for each arc. For comparison, two SBRT plans were respectively generated for each of the 20 retrospective liver cancer cases with multiple lesions. One plan was optimized using the IB & PG algorithm, and the other plan was optimized with a previously reported optimization algorithm that only considered the IB area. Plans were then evaluated and compared using typical dosimetric metrics.ResultsWith the comparable target coverage, IB & PG plans had significantly lower D500cc, D700cc, mean dose (Dmean), and V15 of normal liver tissues when compared to IB plans. The median percent reductions were 3.32% to 5.36%. The D1cc, D5cc, and Dmean for duodenum and small intestine in IB & PG plans were significantly reduced in a range from 7.60% up to 16.03%. Similarly, the median integral dose was reduced by 3.73%. Furthermore, the percentage of normal liver Dmean sparing when IB & PG plans compared to IB plans, was found to be positively correlated (ρ = 0.669, P = 0.001) with the inter‐target distance.ConclusionThe proposed IB & PG algorithm has been demonstrated to outperform the IB algorithm in almost all normal tissue sparing, and the magnitude of liver sparing was positively correlated with inter‐target distance.

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Section: Methodsmentioning

confidence: 99%

Optimization of collimator angle combined island blocking with parked gap achieves superior normal tissue sparing in SBRT planning of multiple liver lesions

Abuduxiku,

Chen,

Zhang

et al. 2024

J Applied Clin Med Phys

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Advances in antitumor effects of pterostilbene and its derivatives

Yu,

Xu,

Gao

et al. 2024

Future Medicinal Chemistry

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Dosimetric comparison in sparing normal tissue dosage by using auto-SBRT planning in oligo liver tumors

Zhang,

Zhan,

Zeng

et al. 2023

Front. Oncol.

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PurposeThe study aimed to compare the dosimetric distribution of VMAT plans by increasing the number of half arcs in liver SBRT and investigate the effect by using automatic plan software in plan optimization.MethodThirty-one patients with oligo liver tumors were randomly selected. VMAT treatment plans with different numbers of coplanar half arcs were generated.ResultAdding arcs significantly increased the PTV, D2%, D50%, and CI, but sacrificed the plan homogeneity. It also decreased the maximum dose of normal tissues such as the stomach, duodenum, and spinal cord and reduced Dmean, D500cc, and D700cc for the liver. Nevertheless, the diminishing effect gradually decayed into three arcs. Meanwhile, the addition of arcs substantially extended the beam-on time.ConclusionIn the context of SBRT for oligo liver tumors, increasing the number of coplanar half arcs will improve PTV conformity and offer better protection for OARs, albeit at the expense of increased treatment duration. Considering the trade-off between plan quality and treatment efficiency, a three-arc plan may be more suitable for clinical implementation.

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Automated treatment planning for liver cancer stereotactic body radiotherapy

Cited by 3 publications

References 37 publications

Optimization of collimator angle combined island blocking with parked gap achieves superior normal tissue sparing in SBRT planning of multiple liver lesions

Optimization of collimator angle combined island blocking with parked gap achieves superior normal tissue sparing in SBRT planning of multiple liver lesions

Advances in antitumor effects of pterostilbene and its derivatives

Dosimetric comparison in sparing normal tissue dosage by using auto-SBRT planning in oligo liver tumors

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