Automated Ultrasound Scanning on a Dual-Modality Breast Imaging System

Sinha, Sumi; Goodsitt, Mitchell M.; Roubidoux, Marilyn A.; Booi, Rebecca C.; LeCarpentier, Gerald L.; Lashbrook, Christine R.; Thomenius, Kai E.; Chalek, C.L.; Carson, Paul L.

doi:10.7863/jum.2007.26.5.645

Cited by 32 publications

(32 citation statements)

References 9 publications

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“…An initial study (151) combined FFDM with three-dimensional automated breast US enabling coregistered dual-modality imaging and was subsequently modified for DBT with automated breast US. Development of a compression paddle compatible for both x-ray and US imaging (152), selection of US coupling media, and breast coverage with US particularly at the breast periphery that is not in contact with the compression paddle have been reported (153). In an analysis of 51 patients with masses (13 malignancies), Padilla et al (154) reported similar AUCs for DBT alone and the combined DBT and automated breast US, and an improvement in discriminating masses from simple cysts.…”

Section: Multimodality Imagingmentioning

confidence: 98%

Digital Breast Tomosynthesis: State of the Art

et al. 2015

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This topical review on digital breast tomosynthesis (DBT) is provided with the intent of describing the state of the art in terms of technology, results from recent clinical studies, advanced applications, and ongoing efforts to develop multimodality imaging systems that include DBT. Particular emphasis is placed on clinical studies. The observations of increase in cancer detection rates, particularly for invasive cancers, and the reduction in false-positive rates with DBT in prospective trials indicate its benefit for breast cancer screening. Retrospective multireader multicase studies show either noninferiority or superiority of DBT compared with mammography. Methods to curtail radiation dose are of importance

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Section: Multimodality Imagingmentioning

confidence: 98%

Digital Breast Tomosynthesis: State of the Art

et al. 2015

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“…It utilizes a Logiq 9 US system with an M12 array by GE Health Systems, Milwaukee, WI. This system functions more effectively with a mesh paddle ( Figure 1) than with the solid paddle employed over the past few years [6,7]. When loosened, the mesh allows substantial local compression by the motor-scanned transducer.…”

Section: A Preliminary Evaluation With Manual Contact Pressure For Lmentioning

confidence: 99%

Local compression in automated breast ultrasound in the mammographic geometry

Carson

Wang

LeCarpentier

et al. 2010

2010 IEEE International Ultrasonics Symposium

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Background, Motivation and Objective: Automated ultrasound scanning (AUS) of the breast has developed more slowly than anticipated. The main limitation, beyond achieving adequate acoustic coupling to the breast, has been excessive shadow artifacts, as reflecting structures at acute angles to the ultrasound beam are not flattened by the transducer as well as in manual scanning. We believe that imaging of the breast in near mammographic compression provides much of the needed flattening. The question under initial study in this effort is, whether in breast AUS under very light mammographic compression, local compression by the transducer might flatten the acutely oriented structures further and reduce the acoustic path length to key structures in the breast. We suspect these improvements will be possible without distorting the breast so dramatically that the lesion registration advantages of scanning the breast in the same system as mammography or digital breast tomosynthesis (DBT) are not realized. Preliminary tests are reported here, as well as design of a system for a more refined human study. Statement of Contribution/Methods: Initial imaging tests were performed in our combined AUS/DBT system. A fiber mesh, loosened slightly in its frame, replaced the standard plastic mammography compression paddle. The transducer, in contact with the mesh and the breast, was translated by motors. The compression force of the linear array transducer on its vertical was manually controlled. Breast phantoms and the breasts of three women were scanned with usual compression by the mesh paddle and then with less global, but added local, compression. Results: Examples of flattened structures were observed more brightly in the locally compressed breasts, and acoustic paths longer than 35 mm were reduced, by ~10 mm. In many areas image penetration was 3 cm greater. In one case, image volumes w/wo local compression were spatially aligned by nonlinear image registration software. Discussion and Conclusions: Visual indicators of image features expected to provide improved ultrasonic imaging were observed with local compression and lateral movement of tissues appeared acceptable. These results motivated design and construction of an apparatus to make local compression practical and safe. It utilizes joystick control of the vertical compression force during scanning, realized by pneumatic actuators attached to the transducer. The air pressure applied to these actuators is also applied to actuators in the joystick for force feedback to the operator. Two miniature vibrators attached to the joystick provide vibrotactile feedback of the reaction torques computed from the measurements of 6 force sensors on the transducer holder. The fail-safe system design insures no pneumatic compression force application to the breast in case of power loss or emergency shutdown.

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“…35 These methods and the effect of using a compression plate for U.S. scanning were addressed. 36 The U.S. system trigger rate was set at 5 Hz resulting in a transducer translation rate of 2 mm/s. One to three parallel 39 mm wide automated B-mode U.S. sweeps were performed as needed to cover the entire breast, depending on its shape and size under compression and to the extent allowed by the achieved acoustic coupling.…”

Section: Iib Setupmentioning

confidence: 99%

“…Our 3D U.S. system has been augmented with a motorized transducer carriage above a special compression plate developed in order to improve the coverage over the whole breast. [33][34][35][36][37][38] U.S. imaging, along with other coherent imaging systems, suffers from speckle noise caused by interference effects between overlapping echoes from randomly distributed structure scatterers that are too small to be resolved. Speckle degrades the signal-to-noise ratio of the image and this could lead to reduced performance in registration compared to most other imaging modalities.…”

Section: Introductionmentioning

confidence: 99%

Spatial registration of temporally separated whole breast 3D ultrasound images

et al. 2009

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The purpose of this study was to evaluate the potential for use of image volume based registration ͑IVBaR͒ to aid in measurement of changes in the tumor during chemotherapy of breast cancer. Successful IVBaR could aid in the detection of such changes in response to neoadjuvant chemotherapy and potentially be useful for routine breast cancer screening and diagnosis. IVBaR was employed in a new method of automated estimation of tumor volume in studies following the radiologist identification of the tumor region in the prechemotherapy scan. The authors have also introduced a new semiautomated method for validation of registration based on Doppler ultrasound ͑U.S.͒ signals that are independent of the grayscale signals used for registration. This Institutional Review Board approved study was conducted on 10 patients undergoing chemotherapy and 14 patients with a suspicious/unknown mass scheduled to undergo biopsy. Reasonably reproducible mammographic positioning and nearly whole breast U.S. imaging were achieved. The image volume was registered offline with a mutual information cost function and global interpolation based on a thin-plate spline using MIAMI FUSE© software developed at the University of Michigan. The success and accuracy of registration of the three dimensional ͑3D͒ U.S. image volume were measured by means of mean registration error ͑MRE͒. IVBaR was successful with MRE of 4.3Ϯ 1.7 mm in 9 out of 10 reproducibility automated breast ultrasound ͑ABU͒ studies and in 12 out of 17 ABU image pairs collected before, during, or after 115Ϯ 14 days of chemotherapy. Semiautomated tumor volume estimation was performed on registered image volumes giving 86Ϯ 8% mean accuracy compared to the radiologist hand-segmented tumor volume on seven cases. Doppler studies yielded fractional volume of color pixels in the region surrounding the lesion and its change with changing breast compression. The Doppler study of patients with detectable blood flow included five patients with suspicious masses and three undergoing chemotherapy. Spatial alignment of the 3D blood vessel data from the Doppler studies provided independent measures for the validation of registration. In 15 Doppler image volume pairs scanned with differing breast compression, the mean centerline separation value was 1.5Ϯ 0.6 mm, while MRE based on a few identifiable structural points common to the two grayscale image volumes was 1.1Ϯ 0.6 mm. Another measure, the overlap ratio of blood vessels, was shown to increase from 0.32 to 0.59 ͑+84%͒ with IVBaR for pairs at various compression levels. These results show that successful registration of ABU scans may be accomplished for comparison and integration of information.

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Automated Ultrasound Scanning on a Dual-Modality Breast Imaging System

Abstract: The challenges of automated ultrasound scanning in a multimodality breast imaging system have been addressed by developing methods to fill in peripheral gaps, minimize patient motion, and register and reconstruct multisweep ultrasound image volumes.

Cited by 32 publications

References 9 publications

Digital Breast Tomosynthesis: State of the Art

Digital Breast Tomosynthesis: State of the Art

Local compression in automated breast ultrasound in the mammographic geometry

Spatial registration of temporally separated whole breast 3D ultrasound images

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