“…The many previous studies have indicated medicinal plants and natural products exert beneficial effects in treatment of COVID-19 ( Din et al, 2020 , Hashem-Dabaghian et al, 2021 , Monfared et al, 2020 ), and also, they demonstrated the hopeful ACE inhibitory activity ( Caballero, 2020 ). In this perspective, a growing body of evidence indicates that Potentilla reptans L. (Rosaceae) can rescue heart dysfunction, oxidative stress, cardiac arrhythmias and apoptosis through inhibiting ROS, glucocorticoid regulated kinase-1 (SGK1), glycogen synthase kinase 3β (GSK-3β), BAX and caspase3 regards to increasing Nrf2, SOD, CAT, NO, BCl-2 and improving cardiac hemodynamic function ( Enayati et al, 2021 , Enayati et al, 2019 , Enayati et al, 2018 , Enayati, xxxx , Wu et al, 2021 , Qi et al, 2022 , Antoine et al, 2022 , Mudiyanselage et al, 2021 ).…”