The evolution of information technology has transformed the design principles of traditional Animation, steering it towards three-dimensional innovation. This study explores the application of 3D animation design within virtual reality (VR) environments, leveraging numerical differential algorithms to calculate pixel coordinates. These coordinates form the basis of line segment differential equations, culminating in the visualization of image elements. These elements are rendered in three dimensions by employing VR technology, creating immersive virtual scenes. The design process, guided by the principle of perspective difference, demonstrates a notable improvement in visual effects compared to conventional methods, receiving an average evaluation score above 6. This advancement not only enhances the aesthetic appeal of Animation but also addresses the limitations of traditional design techniques, offering significant practical benefits.