Automatic Diagnosis of Epileptic Seizure in Electroencephalography Signals Using Nonlinear Dynamics Features

Abstract

Epilepsy is one of the most common neurological disorders generally characterized by sudden and recurrent unprovoked seizures, which is commonly diagnosed through visual inspection of electroencephalography (EEG) signals. However, since EEG signals are highly complex, nonlinear and nonstationary in nature, both visual inspection and the existing computed aid detection approaches fail to capture the intrinsic dynamics of seizure events, leading to unsatisfactory detection performance. Therefore, an accurate computer-aided automatic epileptic seizure diagnosis system is valuable and urgently needed in clinical application. In this study, we propose an automatic classification method using nonlinear dynamics features and nonlinear classifiers for determining whether the EEG signals are in interictal or ictal activities, respectively. The main novelty of this paper is that investigating the performance of discernable entropybased nonlinear dynamics features used for automatic diagnosis of an epileptic seizure. First, the discrete wavelet transform is applied to obtain de-noised and sub-band signals. Second, the nonlinear dynamics features are extracted based on information entropy theory. Subsequently, one-way analysis of variance and forward sequential feature selection technique are employed to identify the most explainable features for seizure detection. Then the selected features are fed to six different classifiers, namely, least squaresupport vector machine (LS-SVM), K-nearest neighbors, logistic regression, linear discriminant analysis, Naive Bayes classifier, and random forest, for automatic diagnosis of the epileptic seizure. Finally, a public EEG dataset from Bonn University, Germany, is utilized to investigate the performance of the proposed method. The experimental results show that the LS-SVM yields the optimal performance with an accuracy of 99.50%, a sensitivity of 100.00%, and a specificity of 99.40%. Our proposed method shows great potential for real-time diagnosis of the epileptic seizures, which can be deployed in hospitals to assist clinicians in accurate diagnosis of seizures.

Analysis of Cardiovascular Changes Caused by Epileptic Seizures in Human Photoplethysmogram Signal

“…techniques such as k-nearest neighbor and Support Vector Machine (SVM) have been extensively researched in literature [33], [34] in the past. Recently, deep neural network techniques have gained attention enabling seizure prediction from preictal EEG patterns with high sensitivity and low FAR [35].…”

Minireview of Epilepsy Detection Techniques Based on Electroencephalogram Signals

“… Ramakrishnan and Murugavel (2019) proposed a new seizure detection model using layered directed acyclic graph SVM (LDAG-SVM), which improved classification accuracy and reduced detection time compared to existing methods. After performing DWT, Chen et al (2019) extracted the non-linear features of each sub-band and inputted them into six different classifiers for training. Finally, they increased the classification accuracy of Least Square-Support Vector Machines (LS-SVM) to 99.5%, which was better than five other classifiers.…”

Çok Seviyeli Dalgacık Dönüşümü ve Yerel İkili Örüntüler Tabanlı Otomatik EEG Duygu Tanıma Yöntemi

“…[2] İnsan duygularının daha iyi tanınması, etkili iletişime yol açacaktır. Duygu tanıma, hastanelerde, akıllı evlerde ve akıllı şehirlerde IOT(nesnelerin interneti) ve akıllı ortamların tanıtılmasıyla son zamanlarda ilgi görmüştür [3] ve teknolojinin artması bu sistemlerin mobil sistemlerde [4][5][6] sağlık hizmetleri [7,8] eğitim [9,10] gibi farklı alanlarda kullanılmasını sağlamıştır.…”

“…Chen vd. [4] beynin aktivite sensörleri sayesinde elde edilen kayıtların analizi sonucu epilepsi nöbetlerinin tespit edilmesi ile ilgili çalışma yaptı.…”