Automatic Generation of Noise-Free Time-Activity Curve With Gated Blood-Pool Emission Tomography Using Deformation of a Reference Curve

Abstract

This paper describes a new method for assessing clinical parameters from a noisy regional time-activity curve (TAC) in tomographic gated blood-pool ventriculography. This method is based on a priori knowledge on the shape of a TAC, and shape approximation. The rejection method was used to generate different random Poisson deviates, covering standard count levels, of six representative TACs in order to test and compare the proposed method with harmonic and multiharmonic reconstruction methods. These methods were compared by evaluating four clinical parameters: time of end systole, amplitude, peak ejection and filling rates. Overall, the accuracy of assessment of these parameters was found to be better with the method described in this paper than with standard multiharmonic fits.

Comparative values of gated blood-pool SPECT and CMR for ejection fraction and volume estimation

“…Correlations were found between GBPS and CMR for all parameters. Using only eight-frame GBPS, we did not find systematic underestimation of EF, thus confirming the results from earlier studies [31,37]. The wider limits of agreement between GBPS and CMR for RVEF can be partly explained by the increased variability in the postprocessing data for the RV using CMR [13] and GBPS [9,18].…”

“…To identify each segmented structure as belonging to the LV, the RV or the vascular structure behind the valve plane, septal, atrioventricular and pulmonary infundibulum planes were defined beforehand. Time-activity curves were generated using deformation of a reference curve as described by Caderas De Kerleau et al [31]. These improvements led to a fully automatic algorithm, except for the precise location of the three aforementioned planes.…”

Actualités en cardiologie isotopique : applications des nouvelles caméras CZT

“…Depuis 2009, un outil logiciel de traitement de données de tomo-ventriculographie isotopique a été mis au point au CHU de Montpellier sur la base de travaux de recherche menés depuis une quinzaine d'années dans le service de médecine nucléaire relatifs à la segmentation automatique des cavités cardiaques et à la modélisation des courbes de vidange ventriculaire [37,38]. L'outil s'appelle TomPool, fonctionne sous Windows, est entièrement gratuit et librement téléchar-geable en ligne (http://scinti.edu.umontpellier.fr/recherche/ logiciels-a-telecharger/).…”

Software Phantom for the Synthesis of Equilibrium Radionuclide Ventriculography Images

“…1 [9], [10]. In particular, the EF is determined at the sample (k = k min , corresponding to TES) where the TAC attains its minimum value.…”

“…The r vi time-activity vector is used in the ventricular TAC model of Kerleau et al [10], to construct the first temporal component v 0 (see (9)) with desired EF and T ES parameters:…”