Abstract. In mountainous areas, damage caused by debris flows is often aggravated by subsequent dam-burst floods within the main river confluence zone. On 30 August 2020, a catastrophic disaster chain occurred at the confluence of the Heixiluo Gully and Niri River in Ganluo County, Southwest China, that consisted of a debris flow, the formation of a barrier lake and subsequent dam breach that flooded the community. This study provides a comprehensive analysis of the damage to buildings resulting from the sequential occurrence of debris flow and dam-burst flood. The peak discharge of the debris flow in the gully mouth reached 1937 m3/s, and the change in the main river channel resulting from the dam-burst flood, which had a peak discharge of 2273 m3/s, resulted in a fourfold increase in the extent of flood inundation compared to an ordinary flood. Three hazard zones were established based on the building damage patterns: (I) primary debris flow burial; (II) secondary dam-burst flood inundation and (III) sequential debris flow burial and dam-burst inundation. Vulnerability curves were developed for Zone (II) and Zone (III) using impact pressures and inundation depths, and a vulnerability assessment chart is presented that contains the three damage categories. This research addresses a gap in the vulnerability assessments of debris flow hazard chains and can support in future disaster mitigation within confluence areas.