This paper adopts the questionnaire survey method and fsQCA analysis method to carry out the empirical analysis about the path of talent cultivation of industry-teaching integration in higher vocational education. Through structural equation modeling to sort out the play mechanism and value realization status quo of applied industry-teaching integration talent cultivation, and accordingly put forward the realization path of the value of applied industry-teaching integration talent cultivation. After analysis, it can be seen that five efficient paths of industry-teaching integration talent cultivation are identified, among which the original coverage of Path 3 is 0.40604, indicating that the current way of industry-teaching integration talent cultivation is still dominated by large enterprises as well as application-oriented. The training content, conditions, and methods of industry-teaching integration have a significant impact on vocational abilities and personality qualities. The degree of influence of applied industry-teaching integration on professional knowledge and skills is between 52.1% and 67.8%, and the degree of influence on quality aspects, such as interpersonal skills, is between 74.9% and 86.3%. Therefore, the findings of this paper can provide a feasible path for enhancing talent through industry-teaching integration in higher vocational colleges and enterprises.