Automatic measurement of prosody in behavioral variant FTD

Nevler, Naomi; Ash, Sharon; Jester, Charles; Irwin, David J.; Liberman, Mark; Grossman, Murray

doi:10.1212/wnl.0000000000004236

Cited by 51 publications

(55 citation statements)

References 35 publications

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“…The sustained ability of nonfluent patients with left frontal damage to mimic fluent speech stimuli, however, is sufficiently well established to be the basis of therapeutic trials in nfvPPA. In addition, contrary to some prior research on bvFTD, we found no diagnostic group differences in standard deviation of fundamental frequency. This negative finding aligns with other research, however, and may represent differences in statistical technique, the speech elicitation task, and/or in the sample selection (e.g., bvFTD is a heterogeneous disorder, and may be prone to unrecognized differences in prosodic accommodation between subtypes).…”

Section: Discussioncontrasting

confidence: 98%

Interpersonal prosodic correlation in frontotemporal dementia

Pressman

Ross

Cohen

et al. 2019

Ann Clin Transl Neurol

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Communication accommodation describes how individuals adjust their communicative style to that of their conversational partner. We predicted that interpersonal prosodic correlation related to pitch and timing would be decreased in behavioral variant frontotemporal dementia (bvFTD). We predicted that the interpersonal correlation in a timing measure and a pitch measure would be increased in right temporal FTD (rtFTD) due to sparing of the neural substrate for speech timing and pitch modulation but loss of social semantics. We found no significant effects in bvFTD, but conversations including rtFTD demonstrated higher interpersonal correlations in speech rate than healthy controls.

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Section: Discussioncontrasting

confidence: 98%

Interpersonal prosodic correlation in frontotemporal dementia

Pressman

Ross

Cohen

et al. 2019

Ann Clin Transl Neurol

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“…Our finding of shorter survival time in patients with significant anterior cingulate atrophy is interesting. Behavioural features in FTD relate to brain networks involving the anterior cingulate cortex . Also, in sporadic bvFTD, anterior cingulate atrophy has been previously recognized as a predictor of disease progression and is involved early in the disease trajectory .…”

Section: Discussionmentioning

confidence: 99%

Predictors of survival and progression in behavioural variant frontotemporal dementia

Agarwal

D‘Mello

Foxe

et al. 2019

Euro J of Neurology

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Background and purpose Predicting the course of behavioural variant frontotemporal dementia (bvFTD) remains a major clinical challenge. This study aimed to identify factors that predict survival and clinical progression in bvFTD. Methods Consecutive patients with clinically probable bvFTD were prospectively followed up over an 8‐year period. Baseline neuropsychological variables, presence of a known pathogenic frontotemporal dementia gene mutation and a systematic visual magnetic resonance imaging assessment at baseline were examined as candidate predictors using multivariate modelling. Results After screening 121 cases, the study cohort consisted of 75 patients with probable bvFTD, with a mean age of 60.8 ± 8.5 years, followed up for a mean duration of 7.2 ± 3.5 years from symptom onset. Median survival time from disease onset was 10.8 years and median survival, prior to transition to nursing home, was 8.9 years. A total of 25 of the 75 patients died during the study follow‐up period. Survival without dependence was predicted by shorter disease duration at presentation (hazard ratio, 0.49, P = 0.001), greater atrophy in the anterior cingulate cortex (hazard ratio, 1.75, P = 0.047), older age (hazard ratio, 1.07, P = 0.026) and a higher burden of behavioural symptoms (hazard ratio, 1.04, P = 0.015). In terms of disease progression, presence of a known pathogenic frontotemporal dementia mutation (β = 0.46, P < 0.001) was the strongest predictor of progression. Deficits in letter fluency (β = −0.43, P = 0.017) and greater atrophy in the motor cortex (β = 0.51, P = 0.03) were also associated with faster progression. Conclusions This study provides novel clinical predictors of survival and progression in bvFTD. Our findings are likely to have an impact on prognostication and care planning in this difficult disease.

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“…Regression analyses have associated poor bvFTD performance on the linguistic measures described above with this anatomic substrate. The limited range of prosodic expression found in bvFTD (Nevler et al 2017) was associated with GM atrophy of the insula and orbital regions of the right frontal lobe, areas frequently diseased in these patients. Anatomic findings in bvFTD associated poor abstract word knowledge with GM atrophy in the inferior frontal gyrus and insula bilaterally (Cousins et al 2016, 2017).…”

Section: Behavioral Variant Frontotemporal Degenerationmentioning

confidence: 93%

“…Notably, prosody also plays a role in nonemotional speech, such as the rising pitch at the end of a question requiring a yes or no response. Nevler et al (2017) conducted an acoustic analysis of a semistructured speech sample in bvFTD. The speech sample was elicited by description of a standard picture known as the cookie theft scene.…”

Section: Behavioral Variant Frontotemporal Degenerationmentioning

confidence: 99%

Linguistic Aspects of Primary Progressive Aphasia

Grossman

2018

Annu. Rev. Linguist.

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Primary progressive aphasia (PPA) refers to a disorder of declining language associated with neurodegenerative diseases such as frontotemporal degeneration and Alzheimer disease. Variants of PPA are important to recognize from a medical perspective because these syndromes are clinical markers suggesting specific underlying pathology. In this review, I discuss linguistic aspects of PPA syndromes that may prove informative for parsing our language mechanism and identifying the neural representation of fundamental elements of language. I focus on the representation of word meaning in a discussion of semantic variant PPA, grammatical comprehension and expression in a discussion of nonfluent/agrammatic variant PPA, the supporting role of short-term memory in a discussion of logopenic variant PPA, and components of language associated with discourse in a discussion of behavioral variant frontotemporal dementia. PPA provides a novel perspective that uniquely addresses facets of language and its disorders while complementing traditional aphasia syndromes that follow stroke.

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Automatic measurement of prosody in behavioral variant FTD

Cited by 51 publications

References 35 publications

Interpersonal prosodic correlation in frontotemporal dementia

Interpersonal prosodic correlation in frontotemporal dementia

Predictors of survival and progression in behavioural variant frontotemporal dementia

Linguistic Aspects of Primary Progressive Aphasia

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