Automatic navigation of an untethered device in the artery of a living animal using a conventional clinical magnetic resonance imaging system

Martel, Sylvain; Mathieu, Jean-Baptiste; Felfoul, Ouajdi; Chanu, Arnaud; Aboussouan, Eric; Tamaz, Samer; Pouponneau, Pierre; Yahia, L’Hocine; Beaudoin, G.; Soulez, Gilles; Mankiewicz, Martin

doi:10.1063/1.2713229

Cited by 318 publications

(243 citation statements)

References 8 publications

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“…5b) with the self-propelling force of the MC-1, would allow magnetic targeting 20 at any depth within a human adult unlike magnetic nanoparticles and carriers 21 that are limited by fast decays of induced forces with distances from the magnetization sources. Depth-independent direct delivery methods such as magnetic resonance navigation 22 cannot be effectively applied to tumoral microenvironments due to the insufficient magnetic induction volume of the agents. Although microscopic artificial swimmers 23 could be envisioned as an alternative to the use of natural microorganisms, embedding an equivalent level of functionality in artificial agents to compete against such natural microorganisms in delivering therapeutics effectively to tumour hypoxic regions may prove to be a far-reaching concept.…”

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confidence: 99%

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

et al. 2016

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Oxygen depleted hypoxic regions in the tumour are generally resistant to therapies1. Although nanocarriers have been used to deliver drugs, the targeting ratios have been very low. Here, we show that the magneto-aerotactic migration behaviour2 of magnetotactic bacteria3, Magnetococcus marinus strain MC-14, can be used to transport drug-loaded nanoliposomes into hypoxic regions of the tumour. In their natural environment, MC-1 cells, each containing a chain of magnetic iron-oxide nanocrystals5, tend to swim along local magnetic field lines and towards low oxygen concentrations6 based on a two-state aerotactic sensing system2. We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in SCID Beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.

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Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

et al. 2016

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“…Several previous works also used a clinical MRI system to guide and position ferromagnetic beads [75,76]. Mathieu at al.…”

Section: Actuation With Magnetic Field Gradientmentioning

confidence: 99%

MRI-based communication for untethered intelligent medical microrobots

Sharafi

Olamaei

2015

J Micro-Bio Robot

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“…In 2007, they reported the control and tracking of a 1.5 mm ferromagnetic bead in the carotid artery (lumen diameter of 5 mm) of a living pig inside a clinical MRI system. 120 They used the orthogonal gradient coil system to apply translational forces on the bead. Recently, they proposed a new strategy, Fringe Field Navigation (FFN), whereby they take advantage of the extremely large field gradients (2-4 T/m) caused by the fringe fields around a MRI scanner, for navigation of magnetic guidewires and catheters in a whole-body area.…”

Section: B1 Magnetically Guided Capsule Gastroscopymentioning

confidence: 99%

Magnetically guided capsule endoscopy

et al. 2017

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Wireless capsule endoscopy (WCE) is a powerful tool for medical screening and diagnosis, where a small capsule is swallowed and moved by means of natural peristalsis and gravity through the human gastrointestinal (GI) tract. The camera-integrated capsule allows for visualization of the small intestine, a region which was previously inaccessible to classical flexible endoscopy. As a diagnostic tool, it allows to localize the sources of bleedings in the middle part of the gastrointestinal tract and to identify diseases, such as inflammatory bowel disease (Crohn's disease), polyposis syndrome, and tumors. The screening and diagnostic efficacy of the WCE, especially in the stomach region, is hampered by a variety of technical challenges like the lack of active capsular position and orientation control. Therapeutic functionality is absent in most commercial capsules, due to constraints in capsular volume and energy storage. The possibility of using body-exogenous magnetic fields to guide, orient, power, and operate the capsule and its mechanisms has led to increasing research in Magnetically Guided Capsule Endoscopy (MGCE). This work shortly reviews the history and state-of-art in WCE technology. It highlights the magnetic technologies for advancing diagnostic and therapeutic functionalities of WCE. Not restricting itself to the GI tract, the review further investigates the technological developments in magnetically guided microrobots that can navigate through the various air-and fluid-filled lumina and cavities in the body for minimally invasive medicine.

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Automatic navigation of an untethered device in the artery of a living animal using a conventional clinical magnetic resonance imaging system

Cited by 318 publications

References 8 publications

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

MRI-based communication for untethered intelligent medical microrobots

Magnetically guided capsule endoscopy

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