Abstract. Data dependence analysis is the foundation to many reordering related compiler optimizations and loop parallelization. Traditional data dependence analysis algorithms are developed primarily for Fortran-like subscripted array variables. They are not very effective for pointer-based references in C or C++. With more advanced hardware support for speculative execution, such as the advanced load instructions in Intel's IA64 architecture, some data dependences with low probability can be speculatively ignored. However, such speculative optimizations must be carefully applied to avoid excessive cost associated with potential mis-speculations. Data dependence profiling is one way to provide probabilistic information on data dependences to guide such speculative optimizations and speculative thread generation.