Automatic Segmentation of the Central Epithelium Imaged With Three Optical Coherence Tomography Devices

Ge, Lili; Shen, Meixiao; Tao, Aizhu; Wang, Jianhua; Dou, Guopeng; Liu, Fan

doi:10.1097/icl.0b013e3182499b64

Cited by 21 publications

(27 citation statements)

References 30 publications

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“…The repeatability of measuring the thickness of the epithelium and Bowman’s layer has been validated by our previous studies using the same method [15,19], and the thickness of the DEC is similar to Bowman’s layer. Shousha et al demonstrated the capability of measuring the DEC thickness using UHR-OCT [20].…”

Section: Methodsmentioning

confidence: 88%

“…It was similar to the device used in previously published studies [15,16]. A superluminescent diode light source (Broadlighter, T840-HP, Superlumdiodes Ltd, Moscow, Russia) with a full width at half maximum bandwidth at 100 nm, centered at 840 nm, was used to provide low coherence light.…”

Section: Methodsmentioning

confidence: 99%

“…The reflectivity profiles obtained by UHR-OCT were used to measure the thickness of the central cornea and associated sub-layers. The corneal laminae were outlined semi-automatically in the exported images (Figure 1) as we described in a previous study [15]. We imaged each layer at the center of cornea, and we used the software [15] that was designed to outline each layer.…”

Section: Methodsmentioning

confidence: 99%

“…The corneal laminae were outlined semi-automatically in the exported images (Figure 1) as we described in a previous study [15]. We imaged each layer at the center of cornea, and we used the software [15] that was designed to outline each layer. Briefly, the software highlighted and locked a point if there was a peak located in the interface.…”

Section: Methodsmentioning

confidence: 99%

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Phacoemulsification Induced Transient Swelling of Corneal Descemet’s Endothelium Complex Imaged with Ultra-High Resolution Optical Coherence Tomography

et al. 2013

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PurposeThickness changes of corneal sub-layers after phacoemulsification were investigated by spectral domain ultra-high resolution optical coherence tomography (UHR-OCT). MethodsThe corneas (n = 26) of 26 age-related cataract surgery patients were studied. UHR-OCT was used to evaluate the thickness of Descemet’s Endothelium Complex (DEC), stroma, Bowman’s layer, epithelium, and full cornea at the center (CCT) before, one day after, and one week after surgery. Non-contact specular microscopy measured CCT, endothelial cell density, and morphology.ResultsThe DEC, stroma, Bowman’s layer, and epithelium were visualized by UHR-OCT. Before surgery, the DEC in all cases appeared as a translucent space between two smooth opaque lines. One day after surgery, the posterior corneal surfaces in half of the eyes were wavy and irregular. Compared to the baseline, one day after surgery the thickness increases of the DEC, stroma, and CCT were 4.3 ± 2.6 µm, 25.5 ± 24.9 µm, and 32.1 ± 26.6 µm, respectively (P < 0.001). The morphology of the DEC and the CCT recovered to baseline one week after surgery (P > 0.05), but endothelial cell density was 8.7% less than at baseline. There were no significant changes in Bowman’s layer and epithelium after the operation. The pre-operative DEC thickness was positively correlated with the decreased endothelial cell density at 1 day after surgery (r = 0.55, P = 0.003).ConclusionsThe DEC showed edematous thickening and different degrees of morphological changes after phacoemulsification. The DEC deformation and corneal edema recovered by one week after surgery, which indicated recovery of endothelial function. UHR-OCT is a useful tool to evaluate function of the DEC after phacoemulsification. Pre-operative DEC thickness may indicate the integrity of the endothelium and could be used for predicting endothelial cell loss after phacoemulsification.

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Section: Methodsmentioning

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Phacoemulsification Induced Transient Swelling of Corneal Descemet’s Endothelium Complex Imaged with Ultra-High Resolution Optical Coherence Tomography

et al. 2013

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“…To reduce the computation time, a limited search region was defined. The border of the central posterior corneal surface was estimated from the peak of axis intensity profiles around the central apex [32,33]. The search was limited to the region below the detected border.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Reliability of Entire Corneal Thickness Mapping in Normal Post-Laser in situ Keratomileusis and Keratoconus Eyes Using Long Scan Depth Spectral Domain Optical Coherence Tomography

Chen

Yang

et al. 2017

Ophthalmic Res

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Purpose: To investigate the repeatability and reproducibility of mapping the entire corneal thickness using spectral domain optical coherence tomography (SD-OCT). Methods: Thirty normal eyes, 30 post-laser in situ keratomileusis (LASIK) surgery eyes, and 30 keratoconus eyes were analyzed. A custom-built long scan depth SD-OCT device was used to obtain entire corneal images. Ten-millimeter-diameter corneal thickness maps were generated by an automated segmentation algorithm. Intraclass correlation coefficients of repeatability (ICC₁) and reproducibility (ICC₂), and coefficients of repeatability (CoR₁) and reproducibility (CoR₂), were calculated to quantify the precision and accuracy of corneal pachymetry measurements using the Bland-Altman method. Results: For SD-OCT measurements in healthy subjects, CoR₁ and CoR₂ were less than 5.00 and 5.53 μm. ICC₁ and ICC₂ were more than 0.997 and 0.996. For SD-OCT measurements in LASIK patients, CoR₁ and CoR₂ were less than 5.09 and 5.34 μm. ICC₁ and ICC₂ were more than 0.997 and 0.996. For SD-OCT measurements in keratoconus patients, CoR₁ and CoR₂ were less than 11.57 and 10.92 μm. ICC₁ and ICC₂ were more than 0.995 and 0.996. Conclusions: The measurements of corneal pachymetric mapping by long scan depth SD-OCT can be assessed over the entire corneal area with good repeatability and reproducibility.

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Corneal Topography, Corneal Tomography, and Epithelial Maps in Keratoconus

Reinstein

Archer

Vida

et al. 2021

New Frontiers for the Treatment of Keratoconus

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Automatic Segmentation of the Central Epithelium Imaged With Three Optical Coherence Tomography Devices

Abstract: The algorithm seemed to be feasible for automatically segmenting the CCT and ET in OCT images using these tested OCT devices. The segmented results were equivalent to that obtained with the manual method.

Cited by 21 publications

References 30 publications

Phacoemulsification Induced Transient Swelling of Corneal Descemet’s Endothelium Complex Imaged with Ultra-High Resolution Optical Coherence Tomography

Phacoemulsification Induced Transient Swelling of Corneal Descemet’s Endothelium Complex Imaged with Ultra-High Resolution Optical Coherence Tomography

Reliability of Entire Corneal Thickness Mapping in Normal Post-Laser in situ Keratomileusis and Keratoconus Eyes Using Long Scan Depth Spectral Domain Optical Coherence Tomography

Corneal Topography, Corneal Tomography, and Epithelial Maps in Keratoconus

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