In our former works we have made serious efforts to improve the performance of medical image analysis methods with using ensemble-based systems. In this paper, we present a novel hardware-based solution for the efficient adoption of our complex, fusion-based approaches for real-time applications. Even though most of the image processing problems and the increasing amount of data have high-performance computing (HPC) demand, there is still a lack of corresponding dedicated HPC solutions for several medical tasks. To widen this bottleneck we have developed a Hybrid Small Size high performance computing Resource (abbreviated by HuSSaR) which efficiently alloys CPU and GPU technologies, mobile and has an own cooling system to support easy mobility and wide applicability. Besides a proper technical description, we include several practical examples from the clinical data processing domain in this work. For more details see also: https://arato.inf.unideb. hu/kovacs.laszlo/research_hybridmicrohpc.html