Automation of dispersive liquid–liquid microextraction and related techniques. Approaches based on flow, batch, flow-batch and in-syringe modes

Alexovič, Michal; Horstkotte, Burkhard; Šrámková, Ivana; Solich, Petr; Sabó, Ján

doi:10.1016/j.trac.2016.10.003

Cited by 93 publications

(33 citation statements)

References 134 publications

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“…2020, 5,1900740 The approach makes use of nano droplet formation for analyte nanoextraction and concentration combined Adv.…”

Section: Discussionmentioning

confidence: 99%

“…[24][25][26] As shown in Figure 1, the liquid was deposited on the spinning substrate and formed a thin film immediately. 2020, 5,1900740 www.advmattechnol.de the droplet volume. After evaporation, the least volatile liquid octanol formed droplets and stayed on the substrate.…”

Section: Fluorescence Detection Of Model Compoundsmentioning

confidence: 99%

“…[41] We obtained the absorption coefficient of nonanoic acid at 1709 cm −1 from our experimental measurements. 2020, 5,1900740 www.advmattechnol.de the droplet diameter ( Figure 3D). Mater.…”

Section: Ir Detection Of Organic Compoundsmentioning

confidence: 99%

“…A high number of LMA nanodroplets formed in the film allowed for capturing nanodroplets with a high spatial resolution. 2020, 5,1900740 www.advmattechnol.de droplets, we can theoretically compare the lifetime of a water thin film with a pinned boundary and a water film without a pinned boundary. A uniform film formed immediately after a drop of LMA/water/ethanol (LMA/W/E) mixture was deposited on the spinning substrate.…”

Section: Concentration and Nanoextraction In An Evaporating Sub-micromentioning

confidence: 99%

“…[4][5][6] DLLME is based on spontaneous emulsification upon mixing of a water-insoluble extractant, a dispersive solvent, and an analyte aqueous solution. The recent development of dispersive liquid-liquid microextraction (DLLME) has stimulated progress for extracting and preconcentrating trace hydrophobic analytes from aqueous solutions both rapidly and efficiently.…”

mentioning

confidence: 99%

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One‐Step Nanoextraction and Ultrafast Microanalysis Based on Nanodroplet Formation in an Evaporating Ternary Liquid Microfilm

Qian

Yamada

Wei

et al. 2019

Adv Materials Technologies

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in chemical analysis workflow is sample pretreatment to extract the analytes before detection. The recent development of dispersive liquid-liquid microextraction (DLLME) has stimulated progress for extracting and preconcentrating trace hydrophobic analytes from aqueous solutions both rapidly and efficiently. [4][5][6] DLLME is based on spontaneous emulsification upon mixing of a water-insoluble extractant, a dispersive solvent, and an analyte aqueous solution. [7,8] The hydrophobic analyte could be rapidly extracted into extractant nanodroplets because of the higher solubility of the analyte in the extractant than in water. The large surface area of nanodroplets enhances the transfer of the analyte from the surrounding solution to the droplets. Relying on the combination of DLLME and various detection techniques, such as inductively coupled plasma optical emission spectrometry or fluorescence spectrometry, trace chemical analysis has been achieved for diverse applications. [9][10][11] However, these existing approaches require significant improvement due to their time-consuming nature, their requirement for specialized equipment in droplet separation and for large volumes of the analyte solution. [12,13] Many studies have focused on concentrating compounds from a single sessile drop evaporation. [14][15][16][17] A common issue comes from the coffee stain effect that leads to uncontrolled deposition of the analyte on the substrate rather than into a focused spot. Although an evaporating drop can shrink isotropically on superhydrophobic surfaces, micro/nanoscale structures on these surfaces can influence solute deposition, in particular at the final stage of evaporation when the drop size becomes comparable with the structures. [18] Supersensitive detection can be achieved for the materials deposited on highly ordered nanostructures on the substrate by using the plasmonic effect. [19] However, these nanostructures are difficult to fabricate for fast and high throughput analysis. Recent work on drop evaporation of ternary liquid mixtures shows advantageous features that may lead to unpinned drop for solute concentrating. [20,21] Selective evaporation of the volatile co-solvent (ethanol) in the mixture leads to oversaturation of oil and consequently spontaneously formation of tiny droplets. This phenomenon of Preconcentration is key for detection from an extremely low concentration solution, but requires separation steps from a large volume of samples using extracting solvents. Here, a simple approach is presented for ultrafast and sensitive microanalysis from a tiny volume of aqueous solutions. In this approach, liquid-liquid nanoextraction in an evaporating thin liquid film on a spinning substrate is coupled with quantitative analysis in one step. The approach is exemplified using a liquid mixture comprising a target compound to be analyzed in water, mixed with extractant oil and co-solvent ethanol. With rapid evaporation of ethanol, nanodroplets of oil form spontaneously in the film. The compounds are highly conce...

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“…2020, 5,1900740 The approach makes use of nano droplet formation for analyte nanoextraction and concentration combined Adv.…”

Section: Discussionmentioning

confidence: 99%

Section: Fluorescence Detection Of Model Compoundsmentioning

confidence: 99%

Section: Ir Detection Of Organic Compoundsmentioning

confidence: 99%

Section: Concentration and Nanoextraction In An Evaporating Sub-micromentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

One‐Step Nanoextraction and Ultrafast Microanalysis Based on Nanodroplet Formation in an Evaporating Ternary Liquid Microfilm

Qian

Yamada

Wei

et al. 2019

Adv Materials Technologies

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Mass transfer enhancement in non‐dispersive solvent extraction with helical hollow fiber enabling Dean vortices

et al. 2017

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In this work mass transfer enhancement of non‐dispersive solvent extraction by use of helical hollow fiber membranes (HHFM) was investigated by means of experiment and model simulation. Purified terephthalic acid wastewater treatment by extraction with p‐xylene as solvent was chosen as the application case. Experiments showed that extraction efficiency of the HHFM was doubly enhanced compared with that of the straight hollow fiber. A comprehensive mathematical model of the HHFM extraction was developed in an orthogonal helical coordinate system with an analytical solution of the 3D velocities. Model simulation revealed that Dean vortices circulate the peripheral fluid to the center, which enhances the mass transfer in the lumen side where radial diffusion is the rate determining step of the extraction. Relations of effluent impurity concentration and enhancement factor with the Graetz number and dimensionless curvature, were obtained by model simulation. Optimal parameters were selected for HHFM extraction design. © 2017 American Institute of Chemical Engineers AIChE J, 63: 3479–3490, 2017

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Dispersive liquid–liquid microextraction of five chlorophenols in water samples followed by determination using capillary electrophoresis

et al. 2018

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Dispersive liquid-liquid microextraction (DLLME) coupled with CE was developed for simultaneous determination of five types of chlorophenols (CPs), namely 2-chlorophenol (2-CP), 4-chlorophenol (4-CP), 2,4-dichlorophenol (2,4-DCP), 2,6-dichlorophenol (2,6-DCP), and 2,4,6-trichlorophenol (2,4,6-TCP) in water samples. Several parameters affecting DLLME and CE conditions were systematically investigated. Under the optimized DLLME-CE conditions, the five CPs were separated completely within 7.5 min and good enrichment factors were obtained of 40, 193, 102, 15, and 107 for 4-CP, 2,4,6-TCP, 2,4-DCP, 2-CP, and 2,6-DCP, respectively. Good linearity was attained in the range of 1-200 μg/L for 2,4,6-TCP, 2,4-DCP, 2-300 μg/L for 4-CP and 2-CP, and 1-300 μg/L for 2,6-DCP, with correlation coefficients (r) over 0.99. The LOD (S/N = 3) and the LOQ (S/N = 10) were 0.31-0.75 μg/L and 1.01-2.43 μg/L, respectively. Recoveries ranging from 60.85 to 112.36% were obtained with tap, lake, and river water spiked at three concentration levels and the RSDs (for n = 3) were 1.31-11.38%. With the characteristics of simplicity, cost-saving, and environmental friendliness, the developed DLLME-CE method proved to be potentially applicable for the rapid, sensitive, and simultaneous determination of trace CPs in complicated water samples.

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Automation of dispersive liquid–liquid microextraction and related techniques. Approaches based on flow, batch, flow-batch and in-syringe modes

Cited by 93 publications

References 134 publications

One‐Step Nanoextraction and Ultrafast Microanalysis Based on Nanodroplet Formation in an Evaporating Ternary Liquid Microfilm

One‐Step Nanoextraction and Ultrafast Microanalysis Based on Nanodroplet Formation in an Evaporating Ternary Liquid Microfilm

Mass transfer enhancement in non‐dispersive solvent extraction with helical hollow fiber enabling Dean vortices

Dispersive liquid–liquid microextraction of five chlorophenols in water samples followed by determination using capillary electrophoresis

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