Automation of sample pretreatment for liquid chromatography

Tolokán, Antal; Horvai, George

doi:10.1007/bf01242185

Cited by 7 publications

(4 citation statements)

References 62 publications

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“…Currently, high efficiency in sample throughput without increased labor is needed in many analytical laboratories. Sample preparation is usually boring, repetitive work and is thus rather susceptible to human errors (32); automated systems have therefore been employed. In some studies an automated solid phase extraction (ASPEC) system has been applied to purify food and feed samples by applying immunoaffinity columns for ochratoxin A and aflatoxin analyses (26,(33)(34)(35)(36).…”

Section: Introductionmentioning

confidence: 99%

Application of Manual and Automated Systems for Purification of Ochratoxin A and Zearalenone in Cereals with Immunoaffinity Columns

Eskola

Kokkonen

Rizzo

2001

J. Agric. Food Chem.

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A manual vacuum manifold and an automated solid phase extraction (ASPEC) system were applied for purification of ochratoxin A and zearalenone in wheat, rye, barley, and oat samples with immunoaffinity columns followed by separation with a high-performance liquid chromatograph and fluorescence detection. The immunoaffinity columns for manual sample purification were purchased from a different manufacturer than were those for the automated system. The limit of detection (LOD) for the method for ochratoxin A with a vacuum manifold and ASPEC was 0.1 microg/kg. For the method for zearalenone, the LODs were 1.5 microg/kg with a vacuum manifold and 3 microg/kg with ASPEC. For the methods for ochratoxin A at spiking levels of 0.6 and 2.5 microg/kg, mean recoveries for different cereals varied from 68 to 106%. For the methods for zearalenone, mean recoveries varied from 78 to 117% at spiking levels of 9 and 25 microg/kg. The relative standard deviations of repeatability with various cereals employing both methods were 2-15 and 2-19% for ochratoxin A and zearalenone, respectively.

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Section: Introductionmentioning

confidence: 99%

Application of Manual and Automated Systems for Purification of Ochratoxin A and Zearalenone in Cereals with Immunoaffinity Columns

Eskola

Kokkonen

Rizzo

2001

J. Agric. Food Chem.

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“…Integrated analyzer platforms are standing out in several aspects in this context. They make use of a standardized, intrinsically safe system for sterile sample collection and also a mostly standardized sample preparation . The processed samples are then fed into analyzers which are tailored to the respective measuring task and analyzed.…”

Section: Examples Of Current Developmentsmentioning

confidence: 99%

Developments and Trends in Industrial Process Analytics for Life Science Applications

et al. 2017

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Process analytics and process analyzer technology are the basis need to address specific requirements of industrial life‐science processes in order to become extensively employed in this area. This is due to a variety of regulatory demands, but also due to the complexity and other challenges of the individual measurement and control tasks. Examples of recent achievements are presented here. Real time information – substance‐specific where appropriate – as a basis for an improved understanding of the processes and for superior automated process control are among the most prominent requirements.

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“…Dabei zeichnen sich integrierte Analysenplattformen in mehrfacher Hinsicht aus. Sie nutzen ein standardisiertes, eigensicheres System zur sterilen Probennahme 49 und eine ebenfalls weitgehend standardisierte Probenvorbereitung 50. Die bearbeiteten Proben werden dann den auf die jeweilige Messaufgabe zugeschnittenen Analysatoren automatisch zugeführt und analysiert.…”

Section: Beispiele Aktueller Entwicklungenunclassified

Entwicklungen und Trends in der industriellen Prozessanalytik für Life‐Science‐Anwendungen

Gerlach

Gross

Steckenreiter

et al. 2016

Chemie Ingenieur Technik

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Prozessanalytik und die ihr zugrundeliegende Prozessanalysentechnik müssen auf die spezifischen Anforderungen an Prozesse in der Life-Science-Industrie eingehen, um dort künftig umfassend eingesetzt zu werden. Dies hängt einerseits mit den vielfältigen regulatorischen Anforderungen zusammen, aber auch mit der Komplexität und anderen Herausforderungen der einzelnen Mess-und Regelaufgaben. Beispiele für aktuell erzielte Ergebnisse werden im vorliegenden Beitrag vorgestellt. Echtzeitinformationen -gegebenenfalls auch stoffspezifisch -als Grundlage eines besseren Prozessverständnisses und einer überlegenen, automatisierten Prozessführung zu gewinnen, gehört dabei zu den wichtigsten Anforderungen.Process analytics and the process analyzer technology it is based on need to address specific requirements of industrial life-science processes in order to become extensively employed in this area. This is due to a variety of regulatory demands, but also due to the complexity and to other challenges of the individual measurement and control tasks. Examples of recent achievements are presented here. Real time information -substance-specific where appropriate -as a basis for an improved understanding of the processes and for superior automated process control are among the most prominent requirements.

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Automation of sample pretreatment for liquid chromatography

Cited by 7 publications

References 62 publications

Application of Manual and Automated Systems for Purification of Ochratoxin A and Zearalenone in Cereals with Immunoaffinity Columns

Application of Manual and Automated Systems for Purification of Ochratoxin A and Zearalenone in Cereals with Immunoaffinity Columns

Developments and Trends in Industrial Process Analytics for Life Science Applications

Entwicklungen und Trends in der industriellen Prozessanalytik für Life‐Science‐Anwendungen

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