2016
DOI: 10.1002/ceat.201500572
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Automation of Solubility Measurements on a Robotic Platform

Abstract: Experimental investigation in the laboratory can be accelerated and supported by miniaturized automation techniques. In the design of unit operations, e.g., for crystallization and precipitation processes or for chromatographic separations where no solids should appear during the run, reliable solubility data are mandatory. The development and validation of a robotic routine for completely automated solubility measurements are introduced. The triple-determination of automated solubility measurements of the mod… Show more

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Cited by 8 publications
(7 citation statements)
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“…The solubility data of amorphous cefmetazole sodium in the binary solvent mixtures (methanol and ethanol) were measured by a gravimetrical method, − which has been verified in our previously published ref and could be briefly described as follows: (1) Preparation of the saturated solution: This step is the same as step 2 of the UV spectroscopic method. (2) Measurement of the concentration of saturated solution: The upper clear saturated solution were filtered by an organic membrane filter (0.22 ÎŒm, Tianjin Legg Technology Co., Ltd, Tianjin, China) and quickly moved into preweighted small beakers.…”
Section: Experimental Sectionmentioning
confidence: 96%
“…The solubility data of amorphous cefmetazole sodium in the binary solvent mixtures (methanol and ethanol) were measured by a gravimetrical method, − which has been verified in our previously published ref and could be briefly described as follows: (1) Preparation of the saturated solution: This step is the same as step 2 of the UV spectroscopic method. (2) Measurement of the concentration of saturated solution: The upper clear saturated solution were filtered by an organic membrane filter (0.22 ÎŒm, Tianjin Legg Technology Co., Ltd, Tianjin, China) and quickly moved into preweighted small beakers.…”
Section: Experimental Sectionmentioning
confidence: 96%
“…The custom-built robotic platform Lipos GXXL from Zinsser Analytics (Frankfurt, Germany) controlled by Zinsser WinLissy software is utilized for automated adsorption. The layout and features of the platform have been presented in detail in related publications [6,7,20]. An earlier study of Schuldt and Schembecker [7] proves that the robotic device is capable of executing an automatic, batchwise adsorption in 8-mL vials.…”
Section: Robotic Platformmentioning
confidence: 99%
“…The custom-built robotic platform in Fig. 1 has been presented in detail by Schuldt and Schembecker [15] and Thygs et al [20]. The control of the robotic platform is ensured using the Zinsser WinLissy software (Zinsser Analytic GmbH).…”
Section: Robotic Platformmentioning
confidence: 99%