Automation of the gas analysis of14C-labelled compounds utilizing a piston-type counter tube

Carbon‐14 labeling of hydrochlorothiazide via [14C]formaldehyde production from [14C]carbon dioxide at ambient temperature

“…LC/MS (M + 1): 295.8 (8.0%) 296.6 (0.7%) 297.8 (100%) 298.9 (8.7%) 299.8 (44.3%) 300.8 (4.5%) 301.9 (3.5%) 302.6 (0.08%) 303.4 (0.16%). 1…”

“…One of the most frequently applied methods for preparation of [ 14 C]formaldehyde is via reduction of 14 CO 2 with LiAlH 4. 1 This method requires strict temperature control to optimize the yield because it is very difficult to stop the reduction process at the stage of formaldehyde. Instead, a mixture of formaldehyde, formic acid, and methanol is formed.…”