Autonomic control of glands and secretion: A comparative view

Holmgren, Susanne; Olsson, Caroline

doi:10.1016/j.autneu.2010.10.008

Cited by 28 publications

(19 citation statements)

References 121 publications

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“…The secretion of gastric acid, either produced to maintain basal levels or triggered by food intake, is regulated by complex mechanisms including neural and endocrine control through neurotransmitters and hormones [51]. Many details of this basic regulation in teleost fish are still unknown and, in addition, such secretion may follow different functional patterns.…”

Section: Discussionmentioning

confidence: 99%

Acidic Digestion in a Teleost: Postprandial and Circadian Pattern of Gastric pH, Pepsin Activity, and Pepsinogen and Proton Pump mRNAs Expression

et al. 2012

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Two different modes for regulation of stomach acid secretion have been described in vertebrates. Some species exhibit a continuous acid secretion maintaining a low gastric pH during fasting. Others, as some teleosts, maintain a neutral gastric pH during fasting while the hydrochloric acid is released only after the ingestion of a meal. Those different patterns seem to be closely related to specific feeding habits. However, our recent observations suggest that this acidification pattern could be modified by changes in daily feeding frequency and time schedule. The aim of this study was to advance in understanding the regulation mechanisms of stomach digestion and pattern of acid secretion in teleost fish. We have examined the postprandial pattern of gastric pH, pepsin activity, and mRNA expression for pepsinogen and proton pump in white seabream juveniles maintained under a light/dark 12/12 hours cycle and receiving only one morning meal. The pepsin activity was analyzed according to the standard protocol buffering at pH 2 and using the actual pH measured in the stomach. The results show how the enzyme precursor is permanently available while the hydrochloric acid, which activates the zymogen fraction, is secreted just after the ingestion of food. Results also reveal that analytical protocol at pH 2 notably overestimates true pepsin activity in fish stomach. The expression of the mRNA encoding pepsinogen and proton pump exhibited almost parallel patterns, with notable increases during the darkness period and sharp decreases just before the morning meal. These results indicate that white seabream uses the resting hours for recovering the mRNA stock that will be quickly used during the feeding process. Our data clearly shows that both daily illumination pattern and feeding time are involved at different level in the regulation of the secretion of digestive juices.

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Section: Discussionmentioning

confidence: 99%

Acidic Digestion in a Teleost: Postprandial and Circadian Pattern of Gastric pH, Pepsin Activity, and Pepsinogen and Proton Pump mRNAs Expression

et al. 2012

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“…The pancreas is innervated by fibers of the sympathetic nervous system (SNS), which regulate pancreatic functions including release of insulin by islet cells and release of digestive enzymes by acinar cells [19, 22]. SNS fibers are activated during chronic stress and release catecholaminergic neurotransmitters that act on adrenoceptors to modulate cell behavior.…”

Section: Introductionmentioning

confidence: 99%

Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment

Kim-Fuchs

Pimentel

et al. 2014

Brain, Behavior, and Immunity

215

169

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Pancreatic cancer cells intimately interact with a complex microenvironment that influences pancreatic cancer progression. The pancreas is innervated by fibers of the sympathetic nervous system (SNS) and pancreatic cancer cells have receptors for SNS neurotransmitters which suggests that pancreatic cancer may be sensitive to neural signaling. In vitro and non-orthotopic in vivo studies showed that neural signaling modulates tumour cell behavior. However the effect of SNS signaling on tumor progression within the pancreatic microenvironment has not previously been investigated. To address this, we used in vivo optical imaging to non-invasively track growth and dissemination of primary pancreatic cancer using an orthotopic mouse model that replicates the complex interaction between pancreatic tumor cells and their microenvironment. Stress-induced neural activation increased primary tumor growth and tumor cell dissemination to normal adjacent pancreas. These effects were associated with increased expression of invasion genes by tumor cells and pancreatic stromal cells. Pharmacological activation of β-adrenergic signaling induced similar effects to chronic stress, and pharmacological β-blockade reversed the effects of chronic stress on pancreatic cancer progression. These findings indicate that neural β-adrenergic signaling regulates pancreatic cancer progression and suggest β-blockade as a novel strategy to complement existing therapies for pancreatic cancer.

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“…As with leukocytes, epithelial cells at many mucosal sites express adrenergic receptors, and NE has been shown to alter epithelial defense functions. These functions include the vectorial secretion of secretory IgA and other defense molecules (Gross et al, 2010; Linden, 1996; Schmidt et al, 2007), interactions of epithelial cells with bacteria (Chen et al, 2006; Green et al, 2003), epithelial mucus, ion and fluid transport (Holmgren and Olsson, 2011), and vectorial cytokine and chemokine secretion (Chiu et al, 2007; Cox et al, 2007; Prause et al, 2003; Salathe, 2002). …”

Section: Introductionmentioning

confidence: 99%

Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells

Brosnahan

Vulchanova

Witta

et al. 2013

Journal of Neuroimmunology

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The vaginal epithelium provides a barrier to pathogens and recruits immune defenses through the secretion of cytokines and chemokines. Several studies have shown that mucosal sites are innervated by norepinephrine-containing nerve fibers. Here we report that norepinephrine potentiates the proinflammatory response of human vaginal epithelial cells to products produced by Staphylococcus aureus, a pathogen that causes menstrual toxic shock syndrome. The cells exhibit immunoreactivity for catecholamine synthesis enzymes and the norepinephrine transporter. Moreover, the cells secrete norepinephrine and dopamine at low concentrations. These results indicate that norepinephrine may serve as an autocrine modulator of proinflammatory responses in the vaginal epithelium.

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Autonomic control of glands and secretion: A comparative view

Cited by 28 publications

References 121 publications

Acidic Digestion in a Teleost: Postprandial and Circadian Pattern of Gastric pH, Pepsin Activity, and Pepsinogen and Proton Pump mRNAs Expression

Acidic Digestion in a Teleost: Postprandial and Circadian Pattern of Gastric pH, Pepsin Activity, and Pepsinogen and Proton Pump mRNAs Expression

Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment

Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells

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