Autonomic control of gut motility: A comparative view

Olsson, Caroline; Holmgren, Susanne

doi:10.1016/j.autneu.2010.07.002

Cited by 58 publications

(56 citation statements)

References 222 publications

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“…There can be no doubt that the main source for nerve fibres in the human mucosa is from submucosal neurons supplemented by the myenteric and extrinsic neurons (Porter et al 1999;Hens et al 2001;Furness 2006;Phillips and Powley 2007;Olsson and Holmgren 2010). As far as we are aware, the complete structure and optimal functional capability of the mucosal plexus does not depend on neurons lying within this plexus.…”

Section: Mucosal Neurons and Mucosal Nerve Fibresmentioning

confidence: 94%

Quantitative evaluation of neurons in the mucosal plexus of adult human intestines

Kramer

Silveira

Jabari

et al. 2011

Histochem Cell Biol

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The consequence of presence versus absence of mucosal neurons is not consistently assessed. Here, we addressed two questions. First, based on resected gut specimens of 65 patients/body donors suffering from different diseases, counts of mucosal neurons per mm(2) were analysed with respect to age, gender and region. Second, we evaluated resected megacolonic specimens of four patients suffering from chronic Chagas' disease. Mucosal wholemounts were triple-stained for calretinin (CALR), peripherin (PER) and human neuronal protein Hu C/D (HU). Counts revealed no clear correlation between the presence of mucosal neurons and age, gender or region. Mucosal neurons were present in 30 of 36 specimens derived from males (83%) and in 20 of 29 from females (69%). The numbers per mm(2) increased from duodenum to ileum (1.7-10.8) and from ascending to sigmoid colon (3.2-9.9). Out of 149 small intestinal mucosal neurons, 47% were co-reactive for CALR, PER and HU (large intestine: 76% of 300 neurons) and 48% for PER and HU only (large intestine: 23%). In 12 megacolonic specimens (each 3 from 4 patients), all 23 mucosal neurons found (1.9 per mm(2)) displayed co-reactivity for CALR, PER and HU. We suggest that the presence or the absence of mucosal neurons is variable, ongoing studies will address our assumption that they correspond in their morphochemical characteristics to submucosal neurons. Furthermore, both the architecture and neuron number of the megacolonic mucosal plexus displayed no dramatic changes indicating that mucosal nerves might be less involved in chagasic/megacolonic neurodegeneration as known from the myenteric plexus.

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Section: Mucosal Neurons and Mucosal Nerve Fibresmentioning

confidence: 94%

Quantitative evaluation of neurons in the mucosal plexus of adult human intestines

Kramer

Silveira

Jabari

et al. 2011

Histochem Cell Biol

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“…Nutrients and hormones also control intestinal motility, and thus transit, but the autonomic 257 nervous system that includes extrinsic and intrinsic (enteric) pathways plays the most 258 important role (Hansen, 2003;Olsson and Holmgren, 2011)(for review see Van Ginneken, 2012). 259…”

Section: Gastrointestinal Transit 243mentioning

confidence: 99%

A review on early gut maturation and colonization in pigs, including biological and dietary factors affecting gut homeostasis

Everaert

Cruchten

Weström

et al. 2017

Animal Feed Science and Technology

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Corresponding author: Nadia Everaert nadia.everaert@ulg.ac.be multiple components of the mucosal immune system. Furthermore, the composition of the 37 intestinal microbial communities seems to be affected by the early postnatal environment, which 38 might also contribute to gut maturation, metabolic and immune development. Understanding 39 the interplay between morphological, functional and immunological maturation, as influenced 40 by early microbial colonization and ingestion of dietary factors, is of utmost importance to 41 identify management and feeding strategies to optimize intestinal health. We discuss some 42 possible implications related to intrauterine growth restriction, and preterm delivery as these 43

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“…ENS is also referred to as the "second brain" because of its capability to function in the absence of nerve inputs from the central nervous system [29] . However, extrinsic nerve pathways contribute to the regulatory mechanisms underlying gut functions [2,[30][31][32] .…”

Section: Classes Of Enteric Neuronsmentioning

confidence: 99%

Diabetes-related alterations in the enteric nervous system and its microenvironment

Bagyánszki

Bódi²

2012

WJD

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Gastric intestinal symptoms common among diabetic patients are often caused by intestinal motility abnormalities related to enteric neuropathy. It has recently been demonstrated that the nitrergic subpopulation of myenteric neurons are especially susceptible to the development of diabetic neuropathy. Additionally, different susceptibility of nitrergic neurons located in different intestinal segments to diabetic damage and their different levels of responsiveness to insulin treatment have been revealed. These findings indicate the importance of the neuronal microenvironment in the pathogenesis of diabetic nitrergic neuropathy. The main focus of this review therefore was to summarize recent advances related to the diabetes-related selective nitrergic neuropathy and associated motility disturbances. Special attention was given to the findings on capillary endothelium and enteric glial cells. Growing evidence indicates that capillary endothelium adjacent to the myenteric ganglia and enteric glial cells surrounding them are determinative in establishing the ganglionic microenvironment. Additionally, recent advances in the development of new strategies to improve glycemic control in type 1 and type 2 diabetes mellitus are also considered in this review. Finally, looking to the future, the recent and promising results of metagenomics for the characterization of the gut microbiome in health and disease such as diabetes are highlighted.

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Autonomic control of gut motility: A comparative view

Cited by 58 publications

References 222 publications

Quantitative evaluation of neurons in the mucosal plexus of adult human intestines

Quantitative evaluation of neurons in the mucosal plexus of adult human intestines

A review on early gut maturation and colonization in pigs, including biological and dietary factors affecting gut homeostasis

Diabetes-related alterations in the enteric nervous system and its microenvironment

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