Autonomic control of pancreatic beta cells: What is known on the regulation of insulin secretion and beta-cell proliferation in rodents and humans

Moullé, Valentine S.

doi:10.1016/j.peptides.2021.170709

Cited by 10 publications

(6 citation statements)

References 100 publications

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“…18 In addition, evidence from many experimental animal data are in agreement with our ndings. 19 Our ndings are in support of the concept that autonomic function may contribute to beta cell response to a glycemic load. [1][2][3]19 Biologically, an imbalance in sympathetic and parasympathetic nerve activity (i.e.…”

Section: Discussionsupporting

confidence: 71%

“…19 Our ndings are in support of the concept that autonomic function may contribute to beta cell response to a glycemic load. [1][2][3]19 Biologically, an imbalance in sympathetic and parasympathetic nerve activity (i.e. overactive sympathetic nerves and underactive parasympathetic nerves) may cause a lower beta cell response to a glycemic load because the parasympathetic nervous system stimulates insulin secretion whereas the sympathetic nervous system exerts an opposite activity.…”

Section: Discussionsupporting

confidence: 71%

“…overactive sympathetic nerves and underactive parasympathetic nerves) may cause a lower beta cell response to a glycemic load because the parasympathetic nervous system stimulates insulin secretion whereas the sympathetic nervous system exerts an opposite activity. [1][2][3]19 Mechanistically, in response to an increase in glucose levels, which is sensed in the pancreas, peripheral organs, and the brain, parasympathetic nerves endings are thought release acetylcholine, which can increase insulin secretion. [1][2][3]19 In our study the association between HRV and beta cell rate sensitivity (an index of rst phase insulin secretion) was the weakest and almost absent.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3]19 Mechanistically, in response to an increase in glucose levels, which is sensed in the pancreas, peripheral organs, and the brain, parasympathetic nerves endings are thought release acetylcholine, which can increase insulin secretion. [1][2][3]19 In our study the association between HRV and beta cell rate sensitivity (an index of rst phase insulin secretion) was the weakest and almost absent. 4 This is not consistent with available literature in which autonomic system seems to in uence the rst phase of insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

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Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo– The Maastricht Study

Rinaldi

Heide

Bonora

et al. 2023

Preprint

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Objective We investigated, using population-based data, whether worse autonomic function, estimated from lower 24-hour heart rate variability (HRV), was associated with beta cell function, assessed from beta cell response during an oral glucose tolerance test (OGTT). Research design and Methods We used cross-sectional data from The Maastricht Study, a population-based cohort study (N=2,007; age, mean ± SD:60 ± 8 years; 52% men; and 24% with type 2 diabetes). We used linear regression analyses with adjustment for potential confounders (demographic, cardiovascular, and lifestyle factors) to study the associations of time- and frequency-domain HRV (composite scores) with overall beta cell response (estimated from a composite score calculated from: C-peptidogenic index, overall insulin secretion, beta cell glucose sensitivity, beta cell potentiation factor, and beta cell rate sensitivity). In addition, we tested for interaction by sex and glucose metabolism status. Results After full adjustment, lower time- and frequency-domain HRV was significantly associated with lower overall beta cell response composite score (standardized beta, -0.055 [-0.098; -0.011] and -0.051 [-0.095; -0.007], respectively). These associations were not modified by sex and there was no consistent pattern of interaction by glucose metabolism status. Conclusion The present study found that worse autonomic function, estimated from lower HRV, was associated with worse beta cell function, estimated from a composite score in a population-based sample which covered the entire spectrum of glucose metabolism. Hence, autonomic dysfunction may contribute to beta cell dysfunction and, ultimately, to the alteration of glucose metabolism status from normal glucose metabolism to prediabetes and type 2 diabetes.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo– The Maastricht Study

Rinaldi

Heide

Bonora

et al. 2023

Preprint

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“…The crucial steps in the stimulus-secretion coupling cascade involve an increase in intracellular ATP concentration, closure of ATP-sensitive potassium channels, membrane depolarization, opening of voltageactivated Ca 2+ channels and an increase in intracellular calcium concentration ([Ca 2+ ] i ), leading ultimately to exocytosis of insulin-containing vesicles. Beta cell response is further modulated by homo-and heterologous cell-to-cell interactions within islets [11][12][13][14], by autonomous nerve control [15][16][17], and by hormones released by the gut [18][19][20]. Of importance, beta cells display complex oscillatory activity and are intrinsically heterogeneous [8,21,22], with differences observed on molecular [23], morphological [24,25] and functional levels [26,27], and it is only due to strong coupling within the islets that beta cells properly respond to glucose excursions.…”

Section: Introductionmentioning

confidence: 99%

Network representation of multicellular activity in pancreatic islets: Technical considerations for functional connectivity analysis

Šterk,

Zhang,

Pohorec

et al. 2024

PLoS Comput Biol

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Within the islets of Langerhans, beta cells orchestrate synchronized insulin secretion, a pivotal aspect of metabolic homeostasis. Despite the inherent heterogeneity and multimodal activity of individual cells, intercellular coupling acts as a homogenizing force, enabling coordinated responses through the propagation of intercellular waves. Disruptions in this coordination are implicated in irregular insulin secretion, a hallmark of diabetes. Recently, innovative approaches, such as integrating multicellular calcium imaging with network analysis, have emerged for a quantitative assessment of the cellular activity in islets. However, different groups use distinct experimental preparations, microscopic techniques, apply different methods to process the measured signals and use various methods to derive functional connectivity patterns. This makes comparisons between findings and their integration into a bigger picture difficult and has led to disputes in functional connectivity interpretations. To address these issues, we present here a systematic analysis of how different approaches influence the network representation of islet activity. Our findings show that the choice of methods used to construct networks is not crucial, although care is needed when combining data from different islets. Conversely, the conclusions drawn from network analysis can be heavily affected by the pre-processing of the time series, the type of the oscillatory component in the signals, and by the experimental preparation. Our tutorial-like investigation aims to resolve interpretational issues, reconcile conflicting views, advance functional implications, and encourage researchers to adopt connectivity analysis. As we conclude, we outline challenges for future research, emphasizing the broader applicability of our conclusions to other tissues exhibiting complex multicellular dynamics.

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Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion

dos Reis Araujo,

Alves,

dos Santos

et al. 2023

Rev Endocr Metab Disord

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Autonomic control of pancreatic beta cells: What is known on the regulation of insulin secretion and beta-cell proliferation in rodents and humans

Cited by 10 publications

References 100 publications

Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo– The Maastricht Study

Lower heart rate variability, an index of worse autonomic function, is associated with worse beta cell response to a glycemic load in vivo– The Maastricht Study

Network representation of multicellular activity in pancreatic islets: Technical considerations for functional connectivity analysis

Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion

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