Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy

Brito, Adriana Soares Xavier de; Moll-Bernardes, Renata; Pinheiro, Martha Valéria Tavares; Camargo, Gabriel Cordeiro; Siqueira, Fabio Paiva Rossini; Oliveira, Renée Sarmento de; Glavam, Adriana Pereira; Almeida, Sérgio Altino de; Holanda, Marcelo Teixeira de; Sangenis, Luiz Henrique Conde; Mendes, Fernanda de Souza Nogueira Sardinha; Rosado-de-Castro, Paulo Henrique; Sousa, Andréa Silvestre de

doi:10.1007/s12350-023-03281-9

Cited by 5 publications

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“…7 While not mandatory, SPECT images can aid in assessing regional myocardial sympathetic activity, which can be compared with myocardial perfusion scintigraphy images to evaluate perfused but denervated areas (mismatch), which are more susceptible to arrhythmias. 9 In anterior planar chest images, the relationship of mIBG-I123 uptake between the heart and mediastinum (H/M) and the myocardial washout rate (WR) were evaluated. The early and late H/M ratio is calculated by averaging counts per pixel in regions of interest drawn in the superior mediastinum (7x7 pixels) and over the entire heart (Figure 2).…”

Section: How Is the Exam Performed?mentioning

confidence: 99%

My Approach to Assess Cardiac Sympathetic Activity

de Brito,

Leite,

Brandão

2024

ABC Imagem Cardiovascular

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Sympathetic innervation plays a crucial role in regulating blood flow, chronotropism, dromotropism, lusitropism, and myocardial inotropism. In several cardiac and neurodegenerative disorders, the autonomic nervous system (ANS) undergoes alterations. Cardiac neuronal imaging can aid in understanding the pathophysiology, diagnosis, and prognosis of these conditions. This article provides a clear and objective overview of the step-by-step procedure for mIBG-I123 scintigraphy, which assesses cardiac sympathetic activity in primary clinical practice settings.

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Section: How Is the Exam Performed?mentioning

confidence: 99%