Autonomic Dysfunction in Fibromyalgia Assessed by the Composite Autonomic Symptoms Scale (COMPASS)

Solano, Carla; Martínez, Agustín Méndez; Becerril, Lizbeth; Vargas, Angélica; Figueroa, Javier; Navarro, Carmen; Ramos-Remus, César; Martı́nez-Lavı́n, Manuel

doi:10.1097/rhu.0b013e3181a1083d

Cited by 59 publications

(44 citation statements)

References 7 publications

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“…Considering that there is a correlation between autonomic dysfunction and symptom severity or quality of life [11], these results may represent clinical benefits to patients who suffer from this condition.…”

Section: Discussionmentioning

confidence: 99%

“…Sympathetic hyperactivity may also be responsible for frequent complaints of cold extremities. Interestingly, a correlation between autonomic dysfunction and symptom severity or quality of life has been previously described [11]. Heart rate variability (HRV) has been used to investigate cardiovascular autonomic modulation as a simple, sensitive, and noninvasive tool [12].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Posteroanterior Thoracic Mobilization on Heart Rate Variability and Pain in Women with Fibromyalgia

Reis

Durigan

Arena

et al. 2014

Rehabilitation Research and Practice

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Fibromyalgia (FM) has been associated with cardiac autonomic abnormalities and pain. Heart rate variability (HRV) is reduced in FM with autonomic tone dominated by sympathetic activity. The purpose of this study was to evaluate the effects of one session of a posteroanterior glide technique on both autonomic modulation and pain in woman with FM. This was a controlled trial with immediate followup; twenty premenopausal women were allocated into 2 groups: (i) women diagnosed with FM (n = 10) and (ii) healthy women (n = 10). Both groups received one session of Maitland mobilization grade III posteroanterior central pressure glide, at 2 Hz for 60 s at each vertebral segment. Autonomic modulation was assessed by HRV and pain by a numeric pain scale before and after the intervention. For HRV analyses, heart rate and RR intervals were recorded for 10 minutes. FM subjects demonstrated reduced HRV compared to controls. Although the mobilization technique did not significantly reduce pain, it was able to improve HRV quantified by an increase in rMSSD and SD1 indices, reflecting an improved autonomic profile through increased vagal activity. In conclusion, women with FM presented with impaired cardiac autonomic modulation. One session of Maitland spine mobilization was able to acutely improve HRV.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Posteroanterior Thoracic Mobilization on Heart Rate Variability and Pain in Women with Fibromyalgia

Reis

Durigan

Arena

et al. 2014

Rehabilitation Research and Practice

View full text Add to dashboard Cite

show abstract

“…It remains to be established if the HRV differences found in this study persist in obese post-menopausal women, in men or in patients with other painful rheumatic syndromes such as rheumatoid arthritis. In this regard, it is worth noting that a previous study revealed that FM patients have significantly more autonomic symptoms (including sleeping problems) than patients with rheumatoid arthritis [26]. Even so, a pending issue is to directly compare nighttime HRV parameters in FM versus other painful rheumatic syndromes.…”

Section: Discussionmentioning

confidence: 99%

Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity

et al. 2011

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IntroductionAt present, there is neither a laboratory test nor an imaging technique able to differentiate people with fibromyalgia (FM) from healthy controls. This lack of an objective biomarker has hampered FM recognition and research. Heart rate variability (HRV) analyses provide a quantitative marker of autonomic nervous system activity. Nighttime is a stable period in which most people are resting. Sleep is modulated by autonomic activity. Sleeping problems are prominent in FM. The objectives of this study are: 1) to explore different nocturnal HRV parameters as potential FM biomarkers and 2) to seek correlation between such HRV parameters and diverse FM symptoms.MethodsWe studied 22 women suffering from FM and 22 age-matched controls. All participants filled out several questionnaires related to FM symptoms. All participants used a Holter monitor over 24 hours while undertaking their routine activities during the day and while sleeping at their homes at night. Time-domain HRV parameters analyzed from 0000 to 0600 hours included, among others: mean normal-normal interbeat intervals (mean NN), standard deviation of the NN intervals (SDNN), and standard deviation of the successive NN differences (SDSD).ResultsNocturnal SDNN of less than 114 ms had the greatest predictive value to set apart patients from controls with an odds ratio of 13.6 (95% confidence interval: 3.9 to 47.8). In patients, decreased nighttime HRV markers indicative of sympathetic predominance had significant correlations with several FM symptoms: SDSD was associated with pain intensity (r = - 0.65, P = 0.001). SDNN correlated with constipation (r = - 0.53, P = 0.001), and mean NN with depression (r = - 0.53, P = 0.001). Controls displayed an opposite behavior. For them, increased nighttime SDNN correlated with Fibromyalgia Impact Questionnaire scores (r = 0.69, P = 0.001) and with other FM symptoms.ConclusionsNocturnal HRV indices indicative of sympathetic predominance are significantly different in FM women when compared to healthy individuals. In FM patients, these HRV parameters correlated with several symptoms including pain severity. Opposite associations were seen in controls. FM may not be just one end of a continuous spectrum of common symptoms. Nocturnal HRV analyses are potential FM biomarkers.

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“…[7] FMS is thought to result from ANS dysfunction initiated by a genetically impaired stress response. [8,9] ANS dysregulation of pain modulatory systems may lead to prolonged interactions among the central nervous system, the peripheral nervous system, and the immune system, such that neuroplasticity establishes a connection among the sympathetic nervous system (SNS) and nocioceptive fibers. This is postulated to result in neuropathic pain.…”

Section: Introductionmentioning

confidence: 99%

Fatigue, sleep, and stress: dynamic relationships in fibromyalgia

McNallen

McCain

Elswick

et al. 2013

Fatigue: Biomedicine, Health & Behavior

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Background: Fibromyalgia (FMS) is a chronic pain syndrome characterized by fatigue and non-restorative sleep. Over 75% of individuals with FMS complain of fatigue and poor sleep. Purpose: The primary aim of this study was to compare 25 women with and 25 women without FMS, on fatigue; autonomic nervous system activity; perceived stress; sleep quality; and immune function. All participants complained of poor sleep, and had been referred to a sleep center for evaluation. The secondary aim was to explore the relationships among those variables within each group and compare those relationships between groups. Methods: A single stage cross-sectional design was used. Results: The FMS group reported greater fatigue, worse sleep, and more autonomic symptoms than the non-FMS group; they evidenced higher tumor necrosis factor alpha (TNF-α) levels. Non-FMS participants with obstructive sleep apnea (OSA) had higher interleukin 1-beta (IL-1β) values than the FMS group. In the FMS group, fatigue was positively correlated with stress, autonomic symptoms, and TNF-α; stress was positively correlated with autonomic symptoms; apnea-hypopnea index (AHI) was negatively correlated with IL-1β levels and total arousals. In the non-FMS group, fatigue was positively correlated with sleep quality; both variables were positively correlated with IL-1β. IL-1β was also positively correlated with TNF-α. Conclusions: Variables that were correlated in the FMS group differed from those in the non-FMS group, except for the correlation of total arousals with AHI.

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Autonomic Dysfunction in Fibromyalgia Assessed by the Composite Autonomic Symptoms Scale (COMPASS)

Cited by 59 publications

References 7 publications

Effects of Posteroanterior Thoracic Mobilization on Heart Rate Variability and Pain in Women with Fibromyalgia

Effects of Posteroanterior Thoracic Mobilization on Heart Rate Variability and Pain in Women with Fibromyalgia

Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity

Fatigue, sleep, and stress: dynamic relationships in fibromyalgia

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