Autonomic dysfunction in patients with essential tremor

Habipoğlu, Yasin; Alpua, Murat; Bilkay, Cemil; Türkel, Yakup; Dağ, Ersel

doi:10.1007/s10072-016-2754-z

Cited by 11 publications

(12 citation statements)

References 13 publications

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“…Further, we observed cardiovascular‐related symptoms in patients with ET along with postural hypotension, excessive sweating, and swallowing disturbances, which might be related to autonomic disorders. Although a literature review did not reveal many related findings, previous self‐reported and objective studies have reported mild autonomic failure, especially regarding the cardiovascular and urogenital systems 31,32 . However, the pathogenesis of the sympathetic and parasympathetic dysfunction in patients with ET remains unknown.…”

Section: Discussionmentioning

confidence: 98%

Distinct non‐motor features of essential tremor with head tremor patients

Peng

et al. 2020

Acta Neurol Scand

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Background There have been few comprehensive scale studies on the non‐motor symptoms (NMS) of patients with essential tremor (ET) with head tremor (ETh) and those with ET without head tremor (ETol). We aimed to explore the motor symptoms and NMS of these two subgroups. Methods We enrolled 199 patients with ET (125, ETol; 74 ETh) and 132 healthy controls. We evaluated motor symptoms using the Fahn‐Tolosa‐Marin Tremor Rating Scale (TRS) and NMS using the Non‐Motor Symptom Scale (NMSS). We compared NMSS scores and the prevalence of each NMS between the patient subgroups. Finally, we conducted a logistic regression analysis of the correlation between head tremor and NMS severity, as well as other determinants. Results There were no significant between‐subgroup differences in demographic characteristics. Further, they presented similar tremor clinical manifestation; however, the ETh subgroup showed a higher prevalence of rest tremor, feeling of sadness, forgetting things or events, and swallowing difficulty, as well as TRS scores, compared with the ETol subgroup. Both patient subgroups showed high scores and prevalence (>50%) in difficulty falling asleep. Logistic regression analysis indicated age as a tremor severity determinant; further, head tremor and tremor severity were NMS determinants. Conclusion Both patient subgroups presented various NMS including sleep disturbances, cognitive deficits, and affective disorders. The ETh subgroup showed a high prevalence of certain NMS aspects including memory and affective disorder; further, they had aggravated NMS. ET with both upper limb tremor and head tremor may be regarded as a more severe clinical subtype.

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Section: Discussionmentioning

confidence: 98%

Distinct non‐motor features of essential tremor with head tremor patients

Peng

et al. 2020

Acta Neurol Scand

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“…The authors found a higher prevalence of abnormal SSR test results in ET patients than controls, indicating sympathetic dysfunction in these patients. 11 …”

Section: Discussionmentioning

confidence: 99%

“… 4 , 5 However, evidence on the association of ET with rapid eye movement (REM) sleep behavior disorder (RBD) 2 or autonomic symptoms remains conflicting. 2 , 9 , 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

Probable REM-Sleep Behavior Disorder and Dysautonomic Symptoms in Essential Tremor

Barbosa

Mendonça

Ladeira

et al. 2017

Tremor and Other Hyperkinetic Movements

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“…Recent autonomic symptom questionnaire-based analyses and sympathetic skin response-based studies have shown a variety of autonomic dysfunctions associated with ET, especially in the fields of cardiovascular and urogenital diseases (90)(91)(92).…”

Section: Heart Rate Variabilitymentioning

confidence: 99%

Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor

Wang

Feng²,

Li³

et al. 2020

Front. Neurol.

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Background: Essential tremor (ET) is manifested as an isolated syndrome of bilateral upper limb action tremor. Parkinson's disease (PD) is the second most common neurodegenerative disease, with typical motor symptoms of bradykinesia, rigidity, and resting tremor. ET-PD describes the new-onset of PD in ET patients. Recently, numerous studies on epidemiology, genetics, pathology, clinical features, and neuroimaging studies are challenging the idea that ET is an isolated disease, suggesting that patients with ET have the tendency to develop PD. Methods: In this review article, we collected recent findings that reveal prodromal markers of PD in patients with ET. Results: Substantia nigra hyperechogenicity serves as a prodromal marker for predicting the development of PD in patients with ET and provides a reference for therapeutic strategies. Additional potential markers include other neuroimaging, clinical features, heart rate, and genetics, whereas others lack sufficient evidence. Conclusion: In consideration of the limited research of PD in patients with ET, we are still far from revealing the prodromal markers. However, from the existing follow-up studies on ET patients, Substantia nigra hyperechogenicity may enable further exploration of the relationship between ET and PD and the search for pathogenesis-based therapies.

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Autonomic dysfunction in patients with essential tremor

Cited by 11 publications

References 13 publications

Distinct non‐motor features of essential tremor with head tremor patients

Distinct non‐motor features of essential tremor with head tremor patients

Probable REM-Sleep Behavior Disorder and Dysautonomic Symptoms in Essential Tremor

Prodromal Markers of Parkinson's Disease in Patients With Essential Tremor

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