Autonomic dysfunction in type 2 diabetes mellitus with and without vascular dementia

Matei, Daniela; Popescu, Cristian D.; Ignat, Bogdan; Matei, Radu

doi:10.1016/j.jns.2012.11.001

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…Diabetes Mellitus affects the peripheral nerves, slows psychomotor responses and has cognitive effects on those individuals who do not have a proper metabolic control. Autonomic dysfunction, [8][9][10] slowing of reflexes can be seen in patients with Type 2 Diabetes Mellitus over a period of time which can lead to increase in the time to react to a number of external stimuli of different modalities. 11 In our study, visual reaction time and auditory reaction time was prolonged in patients with type 2 diabetes mellitus when compared to healthy non-diabetic control group, as shown in Table 1.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Auditory and Visual Reaction Times in Type Ii Diabetic and Non-Diabetic Individuals

Pramila¹,

Sindhu²,

A.V³

et al. 2018

jebmh

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BACKGROUNDDiabetes mellitus over a period produces autonomic dysfunction. It is usually associated with poor prognosis. Reaction time is a simple noninvasive test for peripheral as well as central nervous system. Neurological deficit in patients with diabetes mellitus can be diagnosed by measurement of reaction time before it is clinically evident. Few studies have been done on the effect of type 2 diabetes mellitus on reaction time. Thus, this study was undertaken to determine the effect of type 2 diabetes mellitus on auditory and visual reaction time. MATERIALS AND METHODS25 patients with type 2 diabetes mellitus and 25 healthy, age-matched control group were enrolled based on detailed questionnaire and informed consent was taken from all the subjects. The mean age of type 2 diabetic subjects was 48.8 years and that of control was 48 years. The subjects with type 2 diabetes were on oral medication and of more than 5 years duration. Subjects with history of alcoholism, smoking, history of hypertension, subjects on insulin, complicated cases of diabetes, subjects with visual and auditory disturbances, history of any recent illness, history of peripheral neuropathy, history of muscle weakness, severe anaemia, history of psychological disorders & neurovascular complications are excluded from the study.PC1000Hz reaction timer was used to measure auditory and visual reaction time. RESULTSAuditory and visual reaction times of type 2 diabetes mellitus patients were significantly higher as compared to those of nondiabetic control group. The p value for visual reaction time was 0.001 and that for auditory reaction time was 0.003. CONCLUSIONReaction time measurement can be used for early diagnosis of peripheral neuropathy in patients with type 2 diabetes mellitus before it is clinically manifested. Hence it can be considered as a simple non-invasive method for the early diagnosis of peripheral neuropathy in type 2 diabetes patients.Financial or Other, Competing Interest: None.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study of Auditory and Visual Reaction Times in Type Ii Diabetic and Non-Diabetic Individuals

Pramila¹,

Sindhu²,

A.V³

et al. 2018

jebmh

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“…Therefore, chronic sympathetic over-activity implies the development of T2DM in subjects with tachycardia and/or high PP. Moreover, subjects with diabetes tend to present a certain degree of the autonomic dysfunction leading to elevated RHR and/or PP 39–41 .…”

Section: Discussionmentioning

confidence: 99%

Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population

Wang¹,

Li²,

Liu³

et al. 2017

Sci Rep

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The purpose was to explore the effects of resting heart rate (RHR) and pulse pressure (PP) independently as well as their cumulative effects on the risk of type 2 diabetes mellitus (T2DM) through cross-sectional study plus meta-analysis. A total of 8276 subjects aged 35–74 years from the Rural Diabetes, Obesity and Lifestyle (RuralDiab) study were included in the study. Meanwhile, two meta-analyses were conducted to validate the results of the epidemiological research. The results showed that RHR and PP were associated with higher risk of T2DM, and the corresponding adjusted OR(95%CI) for each quartiles were 1.00, 0.99(0.68–1.42), 1.58(1.13–2.20), 2.93(2.15–3.98) and 1.00, 1.06(0.75–1.48), 1.11(0.79–1.56), 1.45(1.03–2.03), respectively. The cumulative effect analysis indicated that the adjusted OR(95%CI) in the fast RHR-high PP were 3.36(2.26–4.99), 2.60(1.47–4.59), and 3.60(2.09–6.20) compared with the slow RHR-low PP for total population, male and female, respectively. Meta-analysis showed that the pooled effect values for RHR and PP were 1.94(1.64–2.31) and 1.25(1.04–1.51), respectively. This study demonstrated that elevated RHR and PP are independently associated with the risk of T2DM as well as the influences of conventional confounders, and fast RHR with high PP might cumulatively increase the risk of T2DM. However, the potential clinical application remains to be determined.

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“…Bu durumun muhtemel nedenleri arasında diyabetik otonomik disfonksiyon ile iris dokusundaki düz kas, bağ dokusu ve kan damarlarındaki deformasyon sayıl-maktadır. [25][26][27][28] Diyabetik otonomik disfonksiyon, sempatik sinir sistemindeki hasara bağlı olarak parasempatik tonusun baskınlığı ile sonuçlan-maktadır. 24,29,30 Pittasch ve ark.…”

Section: Discussionunclassified

The Effect of Phacoemulsification Surgery on Pupil Size in Diabetic and Nondiabetic Cases

Türk¹,

Aykut²,

Kola³

et al. 2014

Turkiye Klinikleri J Med Sci

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Autonomic dysfunction in type 2 diabetes mellitus with and without vascular dementia

Cited by 12 publications

References 26 publications

A Comparative Study of Auditory and Visual Reaction Times in Type Ii Diabetic and Non-Diabetic Individuals

A Comparative Study of Auditory and Visual Reaction Times in Type Ii Diabetic and Non-Diabetic Individuals

Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population

The Effect of Phacoemulsification Surgery on Pupil Size in Diabetic and Nondiabetic Cases

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