Autonomic Function Tests and <scp>MIBG</scp> in Parkinson's Disease: Correlation to Disease Duration and Motor Symptoms

Rocchi, Chiara; Pierantozzi, Mariangela; Galati, Salvatore; Chiaravalloti, Agostino; Pisani, Valerio; Prosperetti, Chiara; Lauretti, Benedetta; Bassi, Mario Stampanoni; Olivola, Enrica; Schillaci, Orazio

doi:10.1111/cns.12437

Cited by 28 publications

(17 citation statements)

References 37 publications

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“…There is strong evidence that the absence of a BP overshoot and an absence of a HR increase during the Valsalva is pathognomonic for neurogenic OH, occurring in primary and secondary autonomic failure, and the degree of hypotension and/or lack of compensation during forced expiration usually correlate with the degree of autonomic dysfunction and related symptoms. [138][139][140][141][142][143] In contrast, a pronounced BP fall beyond what is normally expected during forced expiration, but a normal chronotropic response during the manoeuvre, may occur in patients with suspected situational syncope, i.e. syncope occurring during some forms of situational syncope, e.g.…”

Section: Valsalva Manoeuvrementioning

confidence: 99%

2018 ESC Guidelines for the diagnosis and management of syncope

Brignole¹,

Moya²,

Lange³

et al. 2018

Kardiol Pol

238

353

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Section: Valsalva Manoeuvrementioning

confidence: 99%

2018 ESC Guidelines for the diagnosis and management of syncope

Brignole¹,

Moya²,

Lange³

et al. 2018

Kardiol Pol

238

353

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“…Impaired motor function is associated with a broad spectrum of human conditions including neurodegenerative diseases, and neurological and neurodevelopmental disorders. For example, Parkinson’s disease (PD), the second most common neurodegenerative disease, is characterized by severe and progressive motor impairment 1 2 . In addition, accumulating evidence indicates that motor impairment is a common feature of early Alzheimer’s disease (AD) 3 4 .…”

mentioning

confidence: 99%

Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice

Mao

Langley

Huang

et al. 2015

Sci Rep

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Evidence has emerged that suggests a link between motor deficits, obesity and many neurological disorders. However, the contributing genetic risk factors are poorly understood. Here we used the Collaborative Cross (CC), a large panel of newly inbred mice that captures 90% of the known variation among laboratory mice, to identify the genetic loci controlling rotarod performance and its relationship with body weight in a cohort of 365 mice across 16 CC strains. Body weight and rotarod performance varied widely across CC strains and were significantly negatively correlated. Genetic linkage analysis identified 14 loci that were associated with body weight. However, 45 loci affected rotarod performance, seven of which were also associated with body weight, suggesting a strong link at the genetic level. Lastly, we show that genes identified in this study overlap significantly with those related to neurological disorders and obesity found in human GWA studies. In conclusion, our results provide a genetic framework for studies of the connection between body weight, the central nervous system and behavior.

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“…This autonomic failure of BP regulation of PD is strongly supported by recent finding that lower urinary track and gastrointestinal dysfunction are common in early PD 52–54 and these non‐motor deficits of during early PD development such as autonomic dysfunction are well described in a recent review article 55 . The better understanding of early autonomic dysfunction and underlying mechanisms is definitely required to offer better therapeutic options to PD patients 56,57 …”

Section: Discussionmentioning

confidence: 75%

Parkinson‐like early autonomic dysfunction induced by vagal application of DOPAL in rats

Sun

Yan

et al. 2021

CNS Neurosci Ther

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Aim To understand why autonomic failures, a common non‐motor symptom of Parkinson's disease (PD), occur earlier than typical motor disorders. Methods Vagal application of DOPAL (3,4‐dihydroxyphenylacetaldehyde) to simulate PD‐like autonomic dysfunction and understand the connection between PD and cardiovascular dysfunction. Molecular and morphological approaches were employed to test the time‐dependent alternation of α‐synuclein aggregation and the ultrastructure changes in the heart and nodose (NG)/nucleus tractus solitarius (NTS). Results Blood pressure (BP) and baroreflex sensitivity of DOPAL‐treated rats were significantly reduced accompanied with a time‐dependent change in orthostatic BP, consistent with altered echocardiography and cardiomyocyte mitochondrial ultrastructure. Notably, time‐dependent and collaborated changes in Mon‐/Tri‐α‐synuclein were paralleled with morphological alternation in the NG and NTS. Conclusion These all demonstrate that early autonomic dysfunction mediated by vagal application of DOPAL highly suggests the plausible etiology of PD initiated from peripheral, rather than central site. It will provide a scientific basis for the prevention and early diagnosis of PD.

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Autonomic Function Tests and MIBG in Parkinson's Disease: Correlation to Disease Duration and Motor Symptoms

Cited by 28 publications

References 37 publications

2018 ESC Guidelines for the diagnosis and management of syncope

2018 ESC Guidelines for the diagnosis and management of syncope

Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice

Parkinson‐like early autonomic dysfunction induced by vagal application of DOPAL in rats

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