Autonomic functions and gastric motility in children with functional abdominal pain disorders

Karunanayake, A.; Rajindrajith, Shaman; Silva, Hitanadura Asita de; Gunawardena, Sampath; Devanarayana, Niranga Manjuri

doi:10.3748/wjg.v25.i1.95

Cited by 11 publications

(2 citation statements)

References 52 publications

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“…Apart from detailed dietary instructions and written information, no further measures to increase dietary compliance were performed in our study (e.g., control of food intake by a nutritional journal). The underlying pathophysiology of FGID with predominant abdominal pain in children is poorly understood and influenced by several factors such as child maltreatment, stressful events, visceral hyperalgesia, lower gastric motility, and alteration in the microbiota [45,46]. The impacts of these factors cannot be excluded and need to be taken into account in the interpretation of our results from a treatment seeking cohort.…”

Section: Discussionmentioning

confidence: 98%

Roles of Lactose and Fructose Malabsorption and Dietary Outcomes in Children Presenting with Chronic Abdominal Pain

et al. 2019

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Intolerance to lactose or fructose is frequently diagnosed in children with chronic abdominal pain (CAP). However, the causal relationship remains a matter of discussion. A cohort of 253 patients, aged 7–12 years, presenting with unexplained CAP received standardized diagnostics. Additional diagnostic tests were performed based on their medical history and physical and laboratory investigations. Fructose and lactose hydrogen breath tests (H2BT) as well as empiric diagnostic elimination diets were performed in 135 patients reporting abdominal pain related to the consumption of lactose or fructose to evaluate carbohydrate intolerance as a potential cause of CAP. Carbohydrate malabsorption by H2BT was found in 55 (41%) out of 135 patients. An abnormal increase in H2BT was revealed in 30% (35/118) of patients after fructose consumption and in 18% (20/114) of patients after lactose administration. Forty-six percent (25/54) reported pain relief during a diagnostic elimination diet. In total, 17 patients had lactose malabsorption, 29 fructose malabsorption, and nine combined carbohydrate malabsorption. Carbohydrate intolerance as a cause of CAP was diagnosed at follow-up in only 18% (10/55) of patients with malabsorption after the elimination of the respective carbohydrate. Thus, carbohydrate malabsorption appears to be an incidental finding in children with functional abdominal pain disorders, rather than its cause. Therefore, testing of carbohydrate intolerance should only be considered in children with a strong clinical suspicion and with the goal to prevent long-term unnecessary dietary restrictions in children suffering from CAP.

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Section: Discussionmentioning

confidence: 98%

Roles of Lactose and Fructose Malabsorption and Dietary Outcomes in Children Presenting with Chronic Abdominal Pain

et al. 2019

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“…Children with functional dyspepsia have been shown to have abnormalities in gastric function, with disorders in both gastric emptying and gastric accommodation. These disturbances include delayed gastric emptying, impaired initial distribution of a meal within the stomach, impaired accommodation, antral hypomotility, gastric dysrhythmia (tachygastria, bradygastria and mixed dysrhythmia), and altered duodenojejunal motility 69 . Abnormal gastric emptying or electrical gastric rhythm have been found in up to 70% of children with functional dyspepsia 70 .…”

Section: Functional Dyspepsiamentioning

confidence: 99%