Autonomic functions in focal epilepsy: A comparison between lacosamide and carbamazepine monotherapy

Izzi, Francesca; Placidi, Fabio; Liguori, Claudio; Posca, Ilaria; Lauretti, Benedetta; Diomedi, Marina; Pisani, Antonio; Mercuri, Nicola Biagio; Rocchi, Chiara

doi:10.1016/j.jns.2020.117095

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…Yet, sodium channel blockers, such as Carbamazepine and Phenytoine are known for their potential cardiac side effects [41,42]. A recently published study investigated Carbamazepine and Lacosamide monotherapy in correlation with HRV and sudomotor function alterations and found that Carbamazepine and Lacosamide did not affect autonomic cardiovascular and sudomotor function compared to controls [43]. In our population sodium channel blockers did not have a significant influence on the results.…”

Section: Limitations Of the Studymentioning

confidence: 48%

Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation

Hödl

Olbert

Mahringer

et al. 2021

Seizure

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Section: Limitations Of the Studymentioning

confidence: 48%

Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation

Hödl

Olbert

Mahringer

et al. 2021

Seizure

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“…Nevertheless, the role of AEDs in the causation of cardiac autonomic neuropathy is controversial. Some authors have reported that carbamazepine use may aggravate autonomic dysfunction in epilepsy patients, whereas others have found no relationship between AED treatment and interictal autonomic dysfunction [8,11,39,46,47]. The absent differences in all autonomic tests between patients with TLE (majority of them on carbamazepine) and patients with IGE (treated with sodium valproate) would minimize the effect of AEDs on the results of this study.…”

Section: Discussionmentioning

confidence: 65%

Interictal autonomic dysfunction in patients with epilepsy

Shaker¹,

Mahdawi

Hamdan

2021

Egypt J Neurol Psychiatry Neurosurg

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Background Autonomic nervous system (ANS) symptoms are frequently present in people with epilepsy (PwE). They are generally more prominent when they originate from the temporal lobe. We aim to investigate the alterations of autonomic functions during the interictal period in patient with temporal lobe epilepsy (TLE) and idiopathic generalized epilepsy (IGE) using heart-based tests, blood pressure (BP)-based tests and sympathetic skin response (SSR). Forty-eight PwE with disease duration ranging from 2 to 15 years and 51 healthy individuals were studied. Long-term electroencephalography (EEG) monitoring, the heart rate variability (HRV) during normal breathing, deep breathing, Valsalva maneuver and standing, BP responses during standing, to isometric hand grip and to mental arithmetic, and the SSR was recorded for all participants. Results 31 patients with TLE and 17 with IGE showed lower RR-IV values during deep breathing, Valsalva maneuver and standing, but not during rest, impaired BP responses during standing, isometric hand grip, and mental arithmetic. Also, prolonged SSR latencies. Within PwE group, no difference was noticed between males and females, nor between the left and right temporal lobes. Conclusion Abnormal autonomic (sympathetic and parasympathetic) regulatory functions suggest that epilepsy may alter the autonomic function and this is not only in TLE but rather in IGE too. These autonomic changes are irrespective of the localization of epilepsy between the two hemispheres. The ANS changes in epileptic patients, particularly those with autonomic symptoms, confirm that electrophysiologic measures of autonomic function may be of value in preventing sudden unexpected death in epilepsy.

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Effect of antipsychotic use by patients with schizophrenia on deceleration capacity and its relation to the corrected QT interval

Okayasu

Shinozaki

Takano

et al. 2023

General Hospital Psychiatry

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Autonomic functions in focal epilepsy: A comparison between lacosamide and carbamazepine monotherapy

Cited by 5 publications

References 29 publications

Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation

Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation

Interictal autonomic dysfunction in patients with epilepsy

Effect of antipsychotic use by patients with schizophrenia on deceleration capacity and its relation to the corrected QT interval

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