Autonomic dysreflexia (AD) is a life-threatening complication of spinal cord injury at T6 or above that results in an uncontrolled sympathetic response secondary to a precipitant. If not recognized as a medical emergency and promptly treated, acute AD may result in devastating complications. Health care providers should be aware of the potential causes of AD and how to treat it when it occurs. This article reviews the acute management of AD, with special consideration to anesthesia and pregnant patients. The key to successful management of recurrent AD is prevention through education, identification, and avoidance of noxious stimuli.