Autonomic neurocardiac function in patients with major depression and effects of antidepressive treatment with nefazodone

Agelink, M.W.; Yavuz, Asiye; Lemmer, W.; Klieser, E.

doi:10.1055/s-2003-825255

Cited by 31 publications

(37 citation statements)

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“…[42][43][44] However, in subjects without cardiovascular diseases conflicting results have been reported and no consensus exists at present. [45][46][47] Furthermore, in the present study, in comparison to most of the other studies, only a subgroup of patients suffered from clinical depression. Eating behaviour related factors such as the subjective hunger score of the TFEQ as well as the binge eating frequency per week instead were related to parasympathetic depression during stress and accounted for the observed group differences.…”

Section: Discussioncontrasting

confidence: 50%

Cardiac parasympathetic regulation in obese women with binge eating disorder

Schild

Schellberg

et al. 2005

Int J Obes

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Objective: Obese individuals with a binge eating disorder (BED) differ from obese non-binge eaters (NBED) with respect to (a) eating behaviour, (b) psychiatric comorbidity and (c) level of psychosocial distress. The aim of the study was to explore whether these three factors have an influence on cardiac parasympathetic function, that is independent of obesity: as alterations in cardiac parasympathetic function may have a role in the higher cardiovascular mortality that is present in obese individuals. Methods: In total, 38 obese women (BMI430 kg/m 2 ), with a BED and 34 age and BMI matched healthy controls (NBED) completed a laboratory stress protocol that incorporated a baseline resting period, Head-up Tilt Testing (HUT) and two challenging mental tasks. Heart rate and blood pressure were measured continuously during the protocol. Parasympathetic cardiac regulation was assessed as the high frequency component of heart rate variability (HRV-HF). Results: Mental challenge led to an augmented reduction of HRV-HF in obese binge eaters, which was linked to the binge eating frequency and hunger perception, but not to psychiatric comorbidity. During baseline conditions and HUT, no significant differences in parasympathetic measures were observed between the two subject groups. Conclusion: Subjects with a BED showed greater reduction in parasympathetic cardiac control (HRV-HF) during mental stress, suggesting higher stress vulnerability in women with a BED. Longitudinal investigations are necessary to evaluate whether this is associated with an increased cardiovascular mortality.

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Section: Discussioncontrasting

confidence: 50%

Cardiac parasympathetic regulation in obese women with binge eating disorder

Schild

Schellberg

et al. 2005

Int J Obes

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“…This study on heart rate variability showed that there are autonomic function disturbances in depressive patients, showing decreased cardiac vagal function, relatively higher sympathetic activity and increased catecholamine secretion (Stein et al, 2000; Agelink et al, 2001), to make the peripheral vas constricted, and increase peripheral resistance. Increased cardiac afterload further decreases the output to inevitably induce decrease of blood pressure especially diastolic pressure, although systolic pressure can still be influenced by peripheral resistance.…”

Section: Discussionmentioning

confidence: 84%

“…In recent years, more attention has been paid to the relationship between major depressive disorder and cardiovascular disease, relevant studies mainly focused on epidemiological investigation (Black and Markides, 1999;Penninx et al, 2001) and pathophysiological mechanism exploration (Laghrissi- Thode et al, 1997;Agelink et al, 2001;Lespérance et al, 2004). To our knowledge, there are no reports on the impairment of cardiovascular function when patients are in depressive state.…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic changes in depressive patients

Zheng

et al. 2006

J. Zhejiang Univ. - Sci. B

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Abstract:Objective: This study is aimed at exploring the relationship between hemodynamic changes and depressive and anxious symptom in depression patients. Methods: The cardiac function indices including the left stroke index (LSI), ejection fraction (EF), heart rate (HR), diastolic pressure mean (DPM), systolic pressure mean (SPM), left ventricle end-diastolic volume (LVDV), effective circulating volume (ECV), resistance total mean (RTM) and blood flow smooth degree (BFSD) were determined in 65 patients with major depressive disorders and 31 healthy normal controls. The clinical symptoms were assessed with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA). Results: In patients with depression without anxiety, LSI, EF, LVDV, DPM, SPM, ECV, BFSD were significantly lower than those in controls, while RTM was higher than that in controls. Patients with comorbidity of depression and anxiety showed decreased LVDV, ECV, BFSD, and increased HR in comparison with the controls. The anxiety/somatization factor score positively correlated with LSI, EF, LVDV, but negatively correlated with RTM. There was negative correlation between retardation factor score and DPM, SPM, LVDV. Conclusion: The study indicated that there are noticeable changes in left ventricle preload and afterload, blood pressure, peripheral resistance, and microcirculation in depressive patients, and that the accompanying anxiety makes the changes more complicated.

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“…In total, 140 case-control and 30 treatment 76,83,93,110,116,129,138,141,155,175,[187][188][189][190][191][192][193][194][195][196][197][198][199][200][201][202][203][204][205][206] studies were eligible for inclusion in the quantitative synthesis (151 case-control and 43 effect sizes for analysis); 10 of the studies were included in both the case-control and treatment analyses. 76,83,93,110,116,129,138,141,155,175 Four subgroups of disorders (mood, anxiety-related, psychotic and substance dependence disorders) and 2 classes of psychotropic medications (antidepressants and antipsychotics) were included. Table 1 reports study characteristics for case-control and treatment studies, separated by diagnostic group or type of psychotropic medication, respectively (see Appendix 1, Tables S1 and S2, for individual study characteristics).…”

Section: Description Of Included Studiesmentioning

confidence: 99%