Autonomic response to the Adult Attachment Projective in anorexia nervosa

Lonigro, Antonia; Pallini, Susanna; Zanna, Valeria; Marech, Lucrezia; Rosa, M.; Criscuolo, Michela; Chianello, Ilenia; Laghi, Fiorenzo

doi:10.1007/s40519-019-00792-8

Cited by 6 publications

(9 citation statements)

References 24 publications

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“…Figure 3 shows the reported or estimated differences in mean resting RRi across studies comparing HRV in AN to a control group. Notably, all but three of the studies (e.g., Lonigro et al, 2019) found large RRi differences with a median value of ∼150 msec. Moreover, the mean difference in resting HR was 12 beats per minute.…”

Section: Resultsmentioning

confidence: 93%

Heart rate variability as a biomarker for anorexia nervosa: A review

Peyser

Scolnick

Hildebrandt

et al. 2020

Euro Eating Disorders Rev

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Objective Anorexia nervosa (AN) typically begins in early adolescence and other than weight status has few reliable biomarkers. Early diagnosis is a critical prognostic factor, but this can be clinically challenging. Heart rate variability (HRV), the beat‐by‐beat variance in heart rate (HR), may provide a unique assessment for the presence of AN because it has clinical utility as a biomarker of cardiac autonomic control in various populations (e.g., athletes, the aged, those with cardiovascular diseases, etc.). We present a review of the literature examining HRV in those with AN. Method Relevant publications were selected from PubMed using the search terms ‘anorexia nervosa AND (HR OR HRV)’. Twenty papers were selected and reviewed. Results The majority of studies suggest that those with AN have markedly and consistently elevated HRV compared to controls, even greater than among young athletes. However, no studies have explored HRV as a biomarker for AN. Discussion Future studies on HRV should elucidate its role as a diagnostic biomarker for AN as well as its responsiveness with serial measurement to track response rates and predict relapse.

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Section: Resultsmentioning

confidence: 93%

Heart rate variability as a biomarker for anorexia nervosa: A review

Peyser

Scolnick

Hildebrandt

et al. 2020

Euro Eating Disorders Rev

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“…Resting HRV was an outcome measure in 27 articles (Kollai et al, 1994 ; Kreipe et al, 1994 ; Petretta et al, 1997 ; Rechlin et al, 1998 ; Casu et al, 2002 ; Galetta et al, 2003 ; Melanson et al, 2004 ; Roche et al, 2004 ; Wu et al, 2004 ; Bar et al, 2006 ; Platisa et al, 2006 ; Murialdo et al, 2007 ; Ishizawa et al, 2008 ; Russell et al, 2008 ; Vigo et al, 2008 ; Lachish et al, 2009 ; Koschke et al, 2010 ; Mazurak et al, 2011b ; Bomba et al, 2014 ; Billeci et al, 2015 , 2019 ; Nakai et al, 2015 ; Rommel et al, 2015 ; Lonigro et al, 2019 ; Lutz et al, 2019 ; Green et al, 2020 ; Tonhajzerova et al, 2020 ) (see Table 3 ). Studies used various durations of HRV assessment; 21 reported HRV outcomes from short-term recordings (Kollai et al, 1994 ; Kreipe et al, 1994 ; Rechlin et al, 1998 ; Casu et al, 2002 ; Wu et al, 2004 ; Bar et al, 2006 ; Murialdo et al, 2007 ; Ishizawa et al, 2008 ; Russell et al, 2008 ; Vigo et al, 2008 ; Lachish et al, 2009 ; Koschke et al, 2010 ; Mazurak et al, 2011b ; Billeci et al, 2015 , 2019 ; Nakai et al, 2015 ; Rommel et al, 2015 ; Lonigro et al, 2019 ; Lutz et al, 2019 ; Green et al, 2020 ; Tonhajzerova et al, 2020 ), five used ambulatory HRV recordings taken over 24 h (Petretta et al, 1997 ; Galetta et al, 2003 ; Roche et al, 2004 ; Platisa et al, 2006 ; Bomba et al, 2014 ) and one stu...…”

Section: Resultsmentioning

confidence: 99%

“…Studies used various durations of HRV assessment; 21 reported HRV outcomes from short-term recordings (Kollai et al, 1994 ; Kreipe et al, 1994 ; Rechlin et al, 1998 ; Casu et al, 2002 ; Wu et al, 2004 ; Bar et al, 2006 ; Murialdo et al, 2007 ; Ishizawa et al, 2008 ; Russell et al, 2008 ; Vigo et al, 2008 ; Lachish et al, 2009 ; Koschke et al, 2010 ; Mazurak et al, 2011b ; Billeci et al, 2015 , 2019 ; Nakai et al, 2015 ; Rommel et al, 2015 ; Lonigro et al, 2019 ; Lutz et al, 2019 ; Green et al, 2020 ; Tonhajzerova et al, 2020 ), five used ambulatory HRV recordings taken over 24 h (Petretta et al, 1997 ; Galetta et al, 2003 ; Roche et al, 2004 ; Platisa et al, 2006 ; Bomba et al, 2014 ) and one study reported both (Melanson et al, 2004 ). Regarding the HRV measures reported, 15 of the included studies reported on time domain HRV (Kollai et al, 1994 ; Petretta et al, 1997 ; Casu et al, 2002 ; Galetta et al, 2003 ; Melanson et al, 2004 ; Roche et al, 2004 ; Bar et al, 2006 ; Platisa et al, 2006 ; Russell et al, 2008 ; Vigo et al, 2008 ; Lachish et al, 2009 ; Koschke et al, 2010 ; Bomba et al, 2014 ; Billeci et al, 2015 , 2019 ), 16 reported low frequency (LF) (Kreipe et al, 1994 ; Petretta et al, 1997 ; Rechlin et al, 1998 ; Casu et al, 2002 ; Galetta et al, 2003 ; Melanson et al, 2004 ; Roche et al, 2004 ; Wu et al, 2004 ; Platisa et al, 2006 ; Murialdo et al, 2007 ; Ishizawa et al, ...…”

Section: Resultsmentioning

confidence: 99%

Section: Heartrate Variabilitymentioning

confidence: 99%

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Autonomic Nervous System Function in Anorexia Nervosa: A Systematic Review

et al. 2021

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Background: Autonomic nervous system (ANS) dysfunction has been suggested to contribute to the high prevalence of cardiovascular complications in individuals with anorexia nervosa (AN), yet has not been thoroughly investigated. The current review aimed to synthesize the evidence of basal ANS function in individuals with a current diagnosis of AN and those with a previous diagnosis who had achieved weight restoration, as compared to controls.Methods: A systematic review of nine databases was conducted and studies that were published in a peer-review journal, in English, that included at least one assessment of ANS function in individuals with a current or previous diagnosis of AN were selected. Forty-six studies were included with a total of 811 participants with a current diagnosis of AN and 123 participants with a previous diagnosis of AN.Results: ANS function was assessed through heart rate variability (n = 27), orthostatic challenge, blood pressure variability or baroreflex sensitivity (n = 11), adrenergic activity (n = 14), skin conductance level (n = 4), and pupillometry (n = 1). Individuals with AN demonstrated increased parasympathetic activity and decreased sympathetic activity, suggestive of autonomic dysregulation. Following weight restoration, autonomic function trended toward, or was equivalent to, control levels.Discussion: Autonomic dysregulation is indicated through a range of assessments in individuals with AN. Future investigations should utilize a variety of assessments together in order to conclusively establish the nature of autonomic dysfunction in AN, and following extended weight restoration. Moreover, investigation into the co-occurrence of ANS function and cardiovascular risk is required.

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“…Changes associated with anorexia nervosa affect both the sympathetic (SNS) and parasympathetic (PNS) branches of the autonomic nervous system (ANS). The most commonly described pathology is the relative predominance of PNS over SNS, resulting in clinical symptoms including bradycardia, hypotension, orthostatic hypotension, and hypothermia [14,[98][99][100][101].…”

Section: Autonomic Nervous Systemmentioning

confidence: 99%

Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa

et al. 2020

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Anorexia nervosa (AN) represents a disorder with the highest mortality rate among all psychiatric diseases, yet our understanding of its pathophysiological components continues to be fragmentary. This article reviews the current concepts regarding AN pathomechanisms that focus on the main biological aspects involving central and peripheral neurohormonal pathways, endocrine function, as well as the microbiome–gut–brain axis. It emerged from the unique complexity of constantly accumulating new discoveries, which hamper the ability to look at the disease in a more comprehensive way. The emphasis is placed on the mechanisms underlying the main symptoms and potential new directions that require further investigation in clinical settings.

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Autonomic response to the Adult Attachment Projective in anorexia nervosa

Cited by 6 publications

References 24 publications

Heart rate variability as a biomarker for anorexia nervosa: A review

Heart rate variability as a biomarker for anorexia nervosa: A review

Autonomic Nervous System Function in Anorexia Nervosa: A Systematic Review

Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa

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