Autonomic studies in hypertensive patient with unusual sexual dysfunction: response to reserpine

Abstract

The authors examined a 48-year-old man with a history of hypertension (6 years) and a history of erection and ejaculation during cold exposure and confrontation with fear (20 years). Exposing the foot to cold water induced ejaculation in 10 seconds. A variety of antihypertensive medications resulted in control of hypertension, without improvement in ejaculatory dysfunction. Similarly, prazosin controlled the blood pressure, but not the episodes of ejaculation. Treatment with reserpine resulted in gradual reduction in blood pressure and an improvement in ejaculatory dysfunction.

Evaluation of an Accurate Mass Approach for the Simultaneous Detection of Drug and Metabolite Distributions via Whole-Body Mass Spectrometric Imaging

“…This observation is consistent with the knowledge that reserpine is extensively metabolized in vivo. Interestingly, detecting drug signal in the testis seems reasonable considering reserpine is known to cause sexual dysfunction side effects. , Extraction of ion images corresponding to the known metabolites methyl reserpate and reserpic acid ,, indicate intense signal in the intestines, as well as, the muscle, thoracic cavity, and liver. Detection of these two analytes in the intestines may be due to local metabolism or biliary elimination of metabolites that were formed in the liver.…”