Split-type flying car will play an important role in the future transportation. This paper adopts a guidance method that couples visual information and depth information, and improves the docking accuracy through the mutual cooperation of the drone and the vehicle. Firstly, a multi-level docking marker is designed to achieve adaptive target matching within different distances during the docking process. The marker has strong robustness and can adapt to complex scenes such as occlusion, strong light, and large angle tilting, providing the redundant corner points required for machine vision detection pose information accurately. Secondly, a three-dimensional pose estimation algorithm is proposed, which can introduce depth information to correct the homography matrix. The algorithm combines the advantages of strong robustness to multi-level marker detection and high accuracy of depth information, and can output millimeter-level precision pose information in different environments, different inclination angles, and different occlusions. Finally, a flying car model experiment was carried out, and the results showed that the guidance technology can obtain millimeter-level precise pose information during the entire process of long distance-near distance-completion of docking, thus realizing precise docking.