Autonomous Motion and Temperature-Controlled Drug Delivery of Mg/Pt-Poly(<i>N</i>-isopropylacrylamide) Janus Micromotors Driven by Simulated Body Fluid and Blood Plasma

Mou, Fangzhi; Chen, Chuanrui; Zhong, Qiang; Yin, Yi; Ma, Hui; Guan, Jianguo

doi:10.1021/am502729y

Cited by 285 publications

(268 citation statements)

References 43 publications

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“…19,20 Drug delivery [21][22][23][24][25][26] and ability for entering into cells by catalytic Janus particles 27 have been examined experimena) Electronic mail: najafi@znu.ac.ir tally. Another interesting application of catalytic micromotors includes water purification that, has been successfully tested.…”

Section: -18mentioning

confidence: 99%

Dynamics of two interacting active Janus particles

Bayati

Najafi

2016

The Journal of Chemical Physics

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Starting from a microscopic model for a spherically symmetric active Janus particle, we study the interactions between two such active motors. The ambient fluid mediates a long range hydrodynamic interaction between two motors. This interaction has both direct and indirect hydrodynamic contributions. The direct contribution is due to the propagation of fluid flow that originated from a moving motor and affects the motion of the other motor. The indirect contribution emerges from the re-distribution of the ionic concentrations in the presence of both motors. Electric force exerted on the fluid from this ionic solution enhances the flow pattern and subsequently changes the motion of both motors. By formulating a perturbation method for very far separated motors, we derive analytic results for the transnational and rotational dynamics of the motors. We show that the overall interaction at the leading order, modifies the translational and rotational speeds of

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Section: -18mentioning

confidence: 99%

Dynamics of two interacting active Janus particles

Bayati

Najafi

2016

The Journal of Chemical Physics

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“…1 Limitations such as poor patient compliance (due to missing or altering dosages) and difficulty in attainment of steady state conditions (as a result of peakvalley plasma concentration fluctuations) have led to poor drug efficacy and toxicity as consequences of underdosing and overdosing of drugs respectively in patients. 2 Drug delivery systems have been designed to overcome these limitations and extend, delay and target drug release [3][4][5][6] . When properly designed, controlled drug delivery systems should be able to deliver drugs at a predetermined rate and manner, either locally or systemically, for a specific period of time after drug administration, which can eliminate excessive fluctuations of drug plasma concentrations.…”

Section: Introductionmentioning

confidence: 99%

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

Ekanem

Nabavi

Vladisavljević

et al. 2015

ACS Appl. Mater. Interfaces

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Biodegradable poly(DL-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) microparticles with tunable size, shape, internal structure and surface morphology were produced by counter-current flow focusing in axisymmetric (3D) glass capillary devices. The dispersed phase was composed of 0.5-2 wt% polymer solution in a volatile 2 organic solvent (ethyl acetate or dichloromethane) and the continuous phase was 5 wt% aqueous poly(vinyl alcohol) solution. The droplets with a coefficient of variation in dripping regime below 2.5 % were evaporated to form polymeric particles with uniform sizes ranging between 4-30 µm. The particle microstructure and surface roughness were modified by adding nanofiller (montmorillonite nanoclay) or porogen (2-methylpentane) in the dispersed phase to form less porous polymer matrix or porous particles with golf-ball-like dimpled surface, respectively. The presence of 2-4 wt% nanoclay in the host polymer significantly reduced the release rate of paracetamol and prevented the early burst release, as a result of reduced polymer porosity and tortuous path for the diffusing drug molecules. Numerical modelling results using the volume of fluid-continuum surface force model agreed well with experimental behaviour and revealed trapping of nanoclay particles in the dispersed phase upstream of the orifice at low dispersed phase flow rates and for 4 wt% nanoclay content, due to vortex formation. Janus PLA/PCL (polycaprolactone) particles were produced by solvent evaporation-induced phase separation within organic phase droplets containing 3 % (v/v) PLA/PCL (30/70 or 70/30) mixture in dichloromethane. A strong preferential adsorption of Rhodamine 6G dye onto PLA was utilized to identify PLA portions of the Janus particles by Confocal Laser Scanning Microscopy (CLSM). Uniform hemispherical PCL particles were produced by dissolution of PLA domes with acetone.

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“…For proof of concept, fluorescein isothiocyanate was used as drug model, achieving complete release after 30 min operating at physiological temperature. It was also shown that those micromotors moved in body fluids and blood plasma quite efficiently [58]. In 2015, Wang et al reported the use of similar micromotors made of poly(3,4-ethylenedioxythiophene)/MnO 2 for camptothecin drug delivery.…”

Section: Chemical Actuation (Catalytic Reactions)mentioning

confidence: 99%

Micro- and nano-motors: the New Generation of Drug Carriers

2018

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Micro-and nano-motors are emerging as novel drug delivery platforms, offering advantages such as rapid drug transport, high tissue penetration and motion controllability. They can be propelled and/or guided by endogenous (i.e., chemotaxis) or exogenous stimuli (e.g., ultrasound, magnetic fields, light) toward the area of interest. Moreover, such stimuli can be used to trigger the release of a therapeutic payload when the motor reaches certain location in order to improve the drug targeting. In this review article, we highlight medically oriented micro-/nano-motors, in particular the ones created for targeted drug delivery, and discuss their current limitations and possibilities toward in vivo applications. Drug-delivery systems have greatly evolved since 1952, when the first sustained release systems were introduced (see the graphical abstract) [1]. In the 1980s, self-regulated drug release carriers as well as the first drug delivery nanostructures were developed. From then on, research in this field has been focused on improving the targeting and systemic circulation of those carriers as well as to study different nanoparticle-based drug formulations, topics which have been widely reviewed in the literature [2][3][4][5][6][7]. Several nanocarriers (between 5 and 200 nm diameter) have been explored for therapy (e.g. inorganic, polymeric, liposomes, nanocrystals, nanotubes and dendrimers) [8], many of them already approved by the Food and Drug Administration (FDA) to treat, for example, neurovascular diseases, neurological cancers and neurodegenerative maladies [9]. The study of their pharmacokinetics has led to the creation of new carriers with reduced drug dose and protection from efflux or degradation [10]. Most of these nanocarriers include sophisticated surface biofunctionalization and coatings like polyethylene glycol (PEG) [11] or biomimetic modifications, [12] to increase their specificity and circulation time [13]. However, challenges still remain for those carriers such as the improvement of their targeting (currently only about 0.7% -median -of the administrated nanoparticle dose is found to be delivered to a solid tumor [14]), their penetration ability, drug loading capacity and delivery on the subcellular level. Other type of drug carriers are the cellular ones, which have many advantages such Graphical abstract:

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Autonomous Motion and Temperature-Controlled Drug Delivery of Mg/Pt-Poly(N-isopropylacrylamide) Janus Micromotors Driven by Simulated Body Fluid and Blood Plasma

Cited by 285 publications

References 43 publications

Dynamics of two interacting active Janus particles

Dynamics of two interacting active Janus particles

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

Micro- and nano-motors: the New Generation of Drug Carriers

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