A model of a superconducting tunnel junction which refrigerates a nearby metallic island without any particle exchange is presented. Heat extraction is mediated by charge fluctuations in the coupling capacitance of the two systems. The interplay of Coulomb interaction and the superconducting gap reduces the power consumption of the refrigerator. The island is predicted to be cooled from lattice temperatures of 200 mK down to close to 50 mK, for realistic parameters. The results emphasize the role of non-equilibrium correlations in bipartite mesoscopic conductors. This mechanism can be applied to create local temperature gradients in tunnel junction arrays or explore the role of interactions in the thermalization of non-equilibrium systems.Quantum coherent processes relevant to quantum information or quantum thermodynamics 1 are usually damaged by temperature. Solid state quantum simulators 2 or heat engines 3,4 have recently been proposed that operate at very low temperatures. Finding ways to cool nanoscale systems 5,6 , or introduce local temperature gradients well below 100 mK without injecting charge into them is hence a demanding task. This way they are minimally perturbed and not affected by Joule heating.Thermoelectric refrigeration is traditionally based on the Peltier effect. Driving a current through a conductor with broken electron-hole symmetry converts thermal excitations into transport. Mesoscopic refrigerators based on this effect make use of semiconductor quantum dots 7,8 , superconducting-insulator-normal metal (SIN) junctions 9-12 , or single-electron transistors (SET) 13,14 . Cooling mediated by the coupling to cavity photons has also been proposed in Josephson junctions 15-17 and implemented for the refrigeration of metallic islands [18][19][20][21][22] . Here an alternative approach is proposed based on the capacitive coupling of a two-terminal SINIS SET to the system to be cooled, see Fig. 1. We consider cooling of a single-electron box (SEB) 23,24 : a Coulomb blockade island which exchanges electrons with a third terminal. The extraction of energy is mediated by the Coulomb repulsion of electrons in different islands, J. The superconducting gap, ∆, acts as an energy filter: At subgap voltages, only transitions that take energy from from the capacitor contribute to transport. A normal metal SET would unavoidably emit Joule heat at all voltages into the island. The manipulation of electrical and thermal flows in capacitively coupled normal metal or semiconductor systems has been recently demonstrated, including effects such as quantum dot heat engines 25-32 , autonomous Maxwell's demon operations 33,34 , thermal rectifiers 35-37 , memristors 38 , or single-electron current switches 39-41 . The interplay of the two relevant energy scales, J and ∆, in the cooling mechanism is investigated. Subgap transport in the SET is assisted by the Coulomb interaction, hence increasing the voltage window where cooling takes place. Hot electrons in the SET island are thus pumped over the gap of the supercond...