2021
DOI: 10.3390/molecules26195967
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Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer

Abstract: Non-small cell lung cancer (NSCLC), an aggressive subtype of pulmonary carcinomas with high mortality, accounts for 85% of all lung cancers. Drug resistance and high recurrence rates impede the chemotherapeutic effect, making it urgent to develop new anti-NSCLC agents. Recently, we have demonstrated that para-toluenesulfonamide is a potential anti-tumor agent in human castration-resistant prostate cancer (CRPC) through inhibition of Akt/mTOR/p70S6 kinase pathway and lipid raft disruption. In the current study,… Show more

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Cited by 5 publications
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“…Cell membrane cholesterol is critical for cancer cell proliferation and survival ( 37 ). Decreased cell membrane cholesterol inhibits the cell proliferation in NSCLC ( 38 ).…”
Section: Discussionmentioning
confidence: 99%
“…Cell membrane cholesterol is critical for cancer cell proliferation and survival ( 37 ). Decreased cell membrane cholesterol inhibits the cell proliferation in NSCLC ( 38 ).…”
Section: Discussionmentioning
confidence: 99%