Autophagy and adipogenesis: Implications in obesity and type II diabetes

Goldman, Scott J.; Zhang, Yong; Jin, Shengkan

doi:10.4161/auto.6.1.10814

Cited by 80 publications

(51 citation statements)

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“…In this regard, inhibiting mitochondrial fission decreases glucose-stimulated insulin secretion in b-cells by accumulating dysfunctional mitochondria resulting from dysregulated autophagy (171). It has been reported that autophagy is associated with diabetes (62,68,110,111,113). It is evident that mitochondrial fission and fusion play an important role in metabolism-secretion coupling of pancreatic b-cells by regulating bioenergetics and homeostasis of mitochondria.…”

Section: Mitochondrial Dynamics In Pancreatic B-cells and Insulin Secmentioning

confidence: 99%

Mitochondrial Dynamics in Diabetes

Yoon

Galloway

Jhun

et al. 2011

Antioxidants & Redox Signaling

190

164

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Mitochondria are at the center of cellular energy metabolism and regulate cell life and death. The cell biological aspect of mitochondria, especially mitochondrial dynamics, has drawn much attention through implications in human pathology, including neurological disorders and metabolic diseases. Mitochondrial fission and fusion are the main processes governing the morphological plasticity and are controlled by multiple factors, including mechanochemical enzymes and accessory proteins. Emerging evidence suggests that mitochondrial dynamics plays an important role in metabolism-secretion coupling in pancreatic b-cells as well as complications of diabetes. This review describes an overview of mechanistic and functional aspects of mitochondrial fission and fusion, and comments on the recent advances connecting mitochondrial dynamics with diabetes and diabetic complications. Antioxid. Redox Signal. 14, 439-457.

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Section: Mitochondrial Dynamics In Pancreatic B-cells and Insulin Secmentioning

confidence: 99%

Mitochondrial Dynamics in Diabetes

Yoon

Galloway

Jhun

et al. 2011

Antioxidants & Redox Signaling

190

164

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“…Adipocyte-specific Atg7-knockout mice exhibited adipocytes with features more characteristic of brown fat than of white AT, being heterogeneous, smaller, containing multiple small lipid droplets and a significant amount of cytoplasm, in contrast to the typical homogenous unilocular cells of wild-type mice. Cells also exhibited a markedly increased number of mitochondria [12,13,18]. At the whole body level white fat depots (gonadal, scapular) were about 20% smaller, with whole body weight being consistently lower.…”

Section: Autophagy and Adipose Tissue Developmentmentioning

confidence: 99%

Autophagy in Adipose Tissue

Maixner¹,

Kovsan²,

Harman-Boehm³

et al. 2012

Obes Facts

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“…1,2 Recent studies have shown that autophagy is upregulated in adipocytes from diabetic mice or obese patients. [3][4][5][6][7][8] Adipose-specific deletion of a key autophagy gene, such as atg5 or atg7, led to lean mice and improved insulin sensitivity and glucose homeostasis in the whole body of mice. 6,7,9 One of the key features with the mouse models was a reduction in the white adipose tissue (WAT) mass, and an increase in the brown adipose tissue (BAT) mass.…”

Section: Introductionmentioning

confidence: 99%