Autophagy and mitophagy in cancer metabolic remodelling

Abstract

Metabolic reprogramming in tumours is now recognized as a hallmark of cancer, participating both in tumour growth and cancer progression. Cancer cells develop global metabolic adaptations allowing them to survive in the low oxygen and nutrient tumour microenvironment. Among these metabolic adaptations, cancer cells use glycolysis but also mitochondrial oxidations to produce ATP and building blocks needed for their high proliferation rate. Another particular adaptation of cancer cell metabolism is the use of autophagy and specific forms of autophagy like mitophagy to recycle intracellular components in condition of metabolic stress or during anticancer treatments. The plasticity of cancer cell metabolism is a major limitation of anticancer treatments and could participate to therapy resistances. The aim of this review is to report recent advances in the understanding of the relationship between tumour metabolism and autophagy/mitophagy in order to propose new therapeutic strategies.

Tubeimoside I induces autophagy in HepG2 cells by activating the AMP‑activated protein kinase signaling pathway

“…Adaptation to the tumor microenvironment (TME) is crucial for tumor cell survival. Metabolic stress is a characteristic of the TME, and most chemotherapeutic agents lead to cellular stress (18). Extracellular stimulation may also induce autophagy; however, its specific function in stress response is not clear.…”

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

“…The process of autophagy, involving degradation of organelles and proteins, plays a crucial role in cellular processes which is associated with elevated ROS levels. Numerous studies have documented the role of ROS regulation in the mediation of autophagy [127,128,129]. The diverse effects of autophagy range from prevention of infection to pathogen elimination to cell death of dysfunctional cellular organelles.…”

Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers

“…This allowed identifying PPARb as an important protagonist in the inhibition of breast cancer cell proliferation and mammary tumor growth under DHA-enriched diet (Wannous et al, 2013). N-3 PUFA have been proposed to regulate autophagy in cancer cells and as such could be involved in both survival and apoptosis, depending on the carcinogenetic phase and the treatment context (Ferro et al, 2020). DHA was found to induce apoptosis in cancer cells (Jing et al, 2011).…”