Autophagy and proinflammatory cytokine expression in the intestinal mucosa and mesenteric fat tissue of patients with Crohn's disease

Leal, Raquel Franco; Milanski, Marciane; Coy, Cláudio Saddy Rodrigues; Portovedo, Mariana; Rodrigues, Viviane Soares; Coope, Andressa; Ayrizono, Maria de Lourdes Setsuko; Fagundes, João José; Velloso, Lı́cio A.

doi:10.1590/s2237-93632013000100003

Cited by 1 publication

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“…Autophagy is required for maintaining intestinal cell survival and a normal colonic mucosa, as well as regulating inflammatory responses. Defects in autophagy-related genes are associated with inflammatory diseases of the gastrointestinal tract detailed below [27,28].…”

Section: Autophagy Overviewmentioning

confidence: 99%

The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis

Elshaer

Begun

2017

Seminars in Cell & Developmental Biology

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Please cite this article as: Elshaer Dana, Begun Jakob.The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis.Seminars in Cell and Developmental Biology http://dx.doi.org/10. 1016/j.semcdb.2016.08.018 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Abstract:Intestinal homeostasis is maintained through the interplay of the intestinal mucosa, local and systemic immune factors, and the microbial content of the gut. The cellular processes of autophagy, endoplasmic reticulum stress, the unfolded protein response and regulation of reactive oxygen species production are required to maintain a balance between proinflammatory responses against potential pathogens and a tolerogenic response towards commensal bacteria. Intestinally active cytokines regulate innate immune pathways and cellular pathways within the gut mucosa. Disruption of these processes, or alterations in the cytokine milieu, can result in an improper response to the commensal gut microbial community leading to inappropriate inflammation characteristic of conditions such as inflammatory bowel disease.

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Section: Autophagy Overviewmentioning

confidence: 99%