2017
DOI: 10.4049/jimmunol.198.supp.203.23
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Autophagy and TGF-β regulates innate immune response in human respiratory syncytial virus infected macrophages

Abstract: Human respiratory syncytial virus (RSV) is a leading cause of hospitalization in infants and children worldwide. RSV infection manifest into two inflammatory diseases, pneumonia and bronchiolitis. Recently, we reported an involvement of transforming growth factor-β (TGF) activated SMAD2/3 signaling pathway in interferon-β (IFN-β) production from RSV infected macrophages. These studies also demonstrated a role of autophagy in triggering TGF production from RSV infected macrophages. Although IFN-β mediated antiv… Show more

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“…CSF-1 had an intermediate effect on the above-mentioned targets as well and a overall tendency for lower expression compared to IL-34 treated microglia. These represent microglia-derived neuroprotective mediators, possibly explaining the health-promoting microglial phenotype associated with ameliorated neuroinflammation where IGF1 and BDNF been associated to MS risk and the latter also linked to microglial autophagy 60,[86][87][88][89] .…”
Section: Il-34 Administration Expands Adam Restricts Autoimmune Neuro...mentioning
confidence: 99%
“…CSF-1 had an intermediate effect on the above-mentioned targets as well and a overall tendency for lower expression compared to IL-34 treated microglia. These represent microglia-derived neuroprotective mediators, possibly explaining the health-promoting microglial phenotype associated with ameliorated neuroinflammation where IGF1 and BDNF been associated to MS risk and the latter also linked to microglial autophagy 60,[86][87][88][89] .…”
Section: Il-34 Administration Expands Adam Restricts Autoimmune Neuro...mentioning
confidence: 99%