Autophagy determines osimertinib resistance through regulation of stem cell-like properties in EGFR-mutant lung cancer

Li, L; Wang, Y; Jiao, Lin; Lin, Caiyu; Lu, Conghua; Zhang, K; Hu, Chen; Ye, J; Zhang, D; Mao, Feng; He, Yong

doi:10.1101/330092

2018

DOI: 10.1101/330092

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Autophagy determines osimertinib resistance through regulation of stem cell-like properties in EGFR-mutant lung cancer

L Li

Y Wang

Lin Jiao

et al.

Abstract: delineates a previously unknown function of autophagy in determining osimertinib resistance through 40 promoting stem-cell like properties. 41All rights reserved. No reuse allowed without permission.(which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.

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Cited by 2 publications

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Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

Chehelgerdi,

Behdarvand Dehkordi,

Chehelgerdi

et al. 2023

Mol Cancer

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The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. The formation of cancer is a multifaceted process influenced by genetic, epigenetic, and environmental factors. iPSCs offer a distinctive platform for investigating the origin of cancer, paving the way for novel approaches to cancer treatment, drug testing, and tailored medical interventions. This review article will provide an overview of the science behind iPSCs, the current limitations and challenges in iPSC-based cancer therapy, the ethical and social implications, and the comparative analysis with other stem cell types for cancer treatment. The article will also discuss the applications of iPSCs in tumorigenesis, the future of iPSCs in tumorigenesis research, and highlight successful case studies utilizing iPSCs in tumorigenesis research. The conclusion will summarize the advancements made in iPSC-based tumorigenesis research and the importance of continued investment in iPSC research to unlock the full potential of these cells.

show abstract

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

Chehelgerdi,

Behdarvand Dehkordi,

Chehelgerdi

et al. 2023

Mol Cancer

View full text Add to dashboard Cite

show abstract

Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer

Gorski

2019

Cancers

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Despite advances in diagnostic tools and therapeutic options, treatment resistance remains a challenge for many cancer patients. Recent studies have found evidence that autophagy, a cellular pathway that delivers cytoplasmic components to lysosomes for degradation and recycling, contributes to treatment resistance in different cancer types. A role for autophagy in resistance to chemotherapies and targeted therapies has been described based largely on associations with various signaling pathways, including MAPK and PI3K/AKT signaling. However, our current understanding of the molecular mechanisms underlying the role of autophagy in facilitating treatment resistance remains limited. Here we provide a comprehensive summary of the evidence linking autophagy to major signaling pathways in the context of treatment resistance and tumor progression, and then highlight recently emerged molecular mechanisms underlying autophagy and the p62/KEAP1/NRF2 and FOXO3A/PUMA axes in chemoresistance.

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Autophagy determines osimertinib resistance through regulation of stem cell-like properties in EGFR-mutant lung cancer

Cited by 2 publications

References 59 publications

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer

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