Autophagy-driven regulation of cisplatin response in human cancers: Exploring molecular and cell death dynamics

Yang, Yang; Liu, Lixia; Tian, Yu; Gu, Miaomiao; Wang, Yanan; Ashrafizadeh, Milad; Reza Aref, Amir; Cañadas, Israel; Klionsky, Daniel J.; Goel, Arul; Reiter, Russel J.; Wang, Yuzhuo; Tambuwala, Murtaza; Zou, Jianyong

doi:10.1016/j.canlet.2024.216659

Cited by 50 publications

(5 citation statements)

References 221 publications

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“…It is also the most curable form of primary liver cancer. The fact that the development of HCC is a multistep process that is also a multigene alteration-induced malignancy with a high level of heterogeneity has been well reported [ 29 – 31 ]. Additionally, the fact that HCC has a high degree of heterogeneity has also been extensively documented.…”

Section: Discussionmentioning

confidence: 99%

A comprehensive analysis of GAS2 family members identifies that GAS2L1 is a novel biomarker and promotes the proliferation of hepatocellular carcinoma

Xu,

Bai,

Zhang

et al. 2024

Discov Onc

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Hepatocellular carcinoma (HCC) is a common primary liver cancer with a high incidence and mortality. Members of the growth-arresting-specific 2 (GAS2) family are involved in various biological processes in human malignancies. To date, there is only a limited amount of information available about the expression profile and clinical importance of GAS2 family in HCC. In this study, we found that GAS2L1 and GAS2L3 were distinctly upregulated in HCC specimens compared to non-tumor specimens. Pan-cancer assays indicated that GAS2L1 and GAS2L3 were highly expressed in most cancers. The Pearson’s correlation revealed that the expressions of GAS2, GAS2L1 and GAS2L2 were negatively associated with methylation levels. Survival assays indicated that GAS2L1 and GAS2L3 were independent prognostic factors for HCC patients. Immune cell infiltration analysis revealed that GAS2, GAS2L1 and GAS2L3 were associated with several immune cells. Finally, we confirmed that GAS2L1 was highly expressed in HCC cells and its knockdown suppressed the proliferation of HCC cells. Taken together, our findings suggested the expression patterns and prognostic values of GAS2 members in HCC, providing insights for further study of the GAS2 family as sensitive diagnostic and prognostic markers for HCC.

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Section: Discussionmentioning

confidence: 99%

A comprehensive analysis of GAS2 family members identifies that GAS2L1 is a novel biomarker and promotes the proliferation of hepatocellular carcinoma

Xu,

Bai,

Zhang

et al. 2024

Discov Onc

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“…Notch3 upregulation in recurrent tumors suggests a role in tumor relapse [126] . The PI3K/AKT pathway enhances OCSC markers, conferring cisplatin and paclitaxel resistance in OC [127] . Akt inhibition (NV-128) induces apoptosis in CD44+/Myeloid Differentiation Primary Response 88 (MyD88)+ OCSCs via Reactive ROS-dependent ERK activation.…”

Section: Ocscs Signaling Pathwaysmentioning

confidence: 99%

“…Akt inhibition (NV-128) induces apoptosis in CD44+/Myeloid Differentiation Primary Response 88 (MyD88)+ OCSCs via Reactive ROS-dependent ERK activation. 2-(4-morpholinyl)-8-phenyl-chromone (LY294002) suppresses Oct 4, ABCG2, and P-gp in SKOV3 OCSCs, potentially reducing chemoresistance [127] . Hepatic leukemia factor (HLF) upregulation in OCSCs maintains OCSCs and confers carboplatin resistance.…”

Section: Ocscs Signaling Pathwaysmentioning

confidence: 99%

Novel players in the development of chemoresistance in ovarian cancer: ovarian cancer stem cells, non-coding RNA and nuclear receptors

Alam,

Giri

2024

Cancer Drug Resist

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Ovarian cancer (OC) ranks as the fifth leading factor for female mortality globally, with a substantial burden of new cases and mortality recorded annually. Survival rates vary significantly based on the stage of diagnosis, with advanced stages posing significant challenges to treatment. OC is primarily categorized as epithelial, constituting approximately 90% of cases, and correct staging is essential for tailored treatment. The debulking followed by chemotherapy is the prevailing treatment, involving platinum-based drugs in combination with taxanes. However, the efficacy of chemotherapy is hindered by the development of chemoresistance, both acquired during treatment (acquired chemoresistance) and intrinsic to the patient (intrinsic chemoresistance). The emergence of chemoresistance leads to increased mortality rates, with many advanced patients experiencing disease relapse shortly after initial treatment. This review delves into the multifactorial nature of chemoresistance in OC, addressing mechanisms involving transport systems, apoptosis, DNA repair, and ovarian cancer stem cells (OCSCs). While previous research has identified genes associated with these mechanisms, the regulatory roles of non-coding RNA (ncRNA) and nuclear receptors in modulating gene expression to confer chemoresistance have remained poorly understood and underexplored. This comprehensive review aims to shed light on the genes linked to different chemoresistance mechanisms in OC and their intricate regulation by ncRNA and nuclear receptors. Specifically, we examine how these molecular players influence the chemoresistance mechanism. By exploring the interplay between these factors and gene expression regulation, this review seeks to provide a comprehensive mechanism driving chemoresistance in OC.

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“…Since Christian de Duve introduced autophagy in 1963, research has made significant strides in understanding its biological aspects and exploring its clinical applications [ 100 , 101 ]. Among the different pathological events in which autophagy is involved in their pathogenesis and progression, cancer has been in the spotlight [ 102 ]. Autophagy has been considered as a suppressor of cancer.…”

Section: Biological Associations Of Nf-ĸbmentioning

confidence: 99%

Versatile function of NF-ĸB in inflammation and cancer

Ma,

Hao,

Hong

et al. 2024

Exp Hematol Oncol

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Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune systems, significantly influencing various physiological processes such as cell proliferation, migration, differentiation, survival, and stemness. The function of NF-ĸB in cancer progression and response to chemotherapy has gained increasing attention. This review highlights the role of NF-ĸB in inflammation control, biological mechanisms, and therapeutic implications in cancer treatment. NF-ĸB is instrumental in altering the release of inflammatory factors such as TNF-α, IL-6, and IL-1β, which are key in the regulation of carcinogenesis. Specifically, in conditions including colitis, NF-ĸB upregulation can intensify inflammation, potentially leading to the development of colorectal cancer. Its pivotal role extends to regulating the tumor microenvironment, impacting components such as macrophages, fibroblasts, T cells, and natural killer cells. This regulation influences tumorigenesis and can dampen anti-tumor immune responses. Additionally, NF-ĸB modulates cell death mechanisms, notably by inhibiting apoptosis and ferroptosis. It also has a dual role in stimulating or suppressing autophagy in various cancers. Beyond these functions, NF-ĸB plays a role in controlling cancer stem cells, fostering angiogenesis, increasing metastatic potential through EMT induction, and reducing tumor cell sensitivity to chemotherapy and radiotherapy. Given its oncogenic capabilities, research has focused on natural products and small molecule compounds that can suppress NF-ĸB, offering promising avenues for cancer therapy.

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Autophagy-driven regulation of cisplatin response in human cancers: Exploring molecular and cell death dynamics

Cited by 50 publications

References 221 publications

A comprehensive analysis of GAS2 family members identifies that GAS2L1 is a novel biomarker and promotes the proliferation of hepatocellular carcinoma

A comprehensive analysis of GAS2 family members identifies that GAS2L1 is a novel biomarker and promotes the proliferation of hepatocellular carcinoma

Novel players in the development of chemoresistance in ovarian cancer: ovarian cancer stem cells, non-coding RNA and nuclear receptors

Versatile function of NF-ĸB in inflammation and cancer

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