Autophagy in cancers including brain tumors: role of MicroRNAs

Pourhanifeh, Mohammad Hossein; Mahjoubin‐Tehran, Maryam; Karimzadeh, Mohammad Reza; Razavi, Zahra; Sahebkar, Amirhossein; Hosseini, Nayyerehsadat; Mirzaei, Hamed; Hamblin, Michael R.

doi:10.1186/s12964-020-00587-w

Cited by 45 publications

(27 citation statements)

References 244 publications

(219 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous in vitro and in vivo studies have demonstrated that TMZ treatment induced apoptosis and autophagy simultaneously in GBM, and the pro-survival role of autophagy is considered part of the TMZ-resistance mechanisms 9 , 17 – 20 . When treated with TMZ, the protein expression levels of ATG5 and LC3B, representative autophagy markers, were increased only in TMZ-resistant LN18 and LN229 cells but not in TMZ-sensitive A172 and U373 cells (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma

et al. 2020

View full text Add to dashboard Cite

Temozolomide (TMZ) is widely used for treating glioblastoma multiforme (GBM), however, the treatment of such brain tumors remains a challenge due to the development of resistance. Increasing studies have found that TMZ treatment could induce autophagy that may link to therapeutic resistance in GBM, but, the precise mechanisms are not fully understood. Understanding the molecular mechanisms underlying the response of GBM to chemotherapy is paramount for developing improved cancer therapeutics. In this study, we demonstrated that the loss of DOC-2/DAB2 interacting protein (DAB2IP) is responsible for TMZ-resistance in GBM through ATG9B. DAB2IP sensitized GBM to TMZ and suppressed TMZ-induced autophagy by negatively regulating ATG9B expression. A higher level of ATG9B expression was associated with GBM compared to low-grade glioma. The knockdown of ATG9B expression in GBM cells suppressed TMZ-induced autophagy as well as TMZ-resistance. Furthermore, we showed that DAB2IP negatively regulated ATG9B expression by blocking the Wnt/β-catenin pathway. To enhance the benefit of TMZ and avoid therapeutic resistance, effective combination strategies were tested using a small molecule inhibitor blocking the Wnt/β-catenin pathway in addition to TMZ. The combination treatment synergistically enhanced the efficacy of TMZ in GBM cells. In conclusion, the present study identified the mechanisms of TMZ-resistance of GBM mediated by DAB2IP and ATG9B which provides insight into a potential strategy to overcome TMZ chemo-resistance.

show abstract

Section: Resultsmentioning

confidence: 99%

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Autophagy is a form of programmed cell death, and is a highly conserved cellular process designed to dispose of damaged cellular organelles or protein aggregates ( Pourhanifeh et al, 2020 ). Autophagy is activated in many viral infections such as HSV-1, HBV, and influenza A virus (IAV).…”

Section: Host Circrnas and Viral Infectionsmentioning

confidence: 99%

Circular RNAs: New Epigenetic Signatures in Viral Infections

et al. 2020

Self Cite

View full text Add to dashboard Cite

Covalent closed circular RNAs (circRNAs) can act as a bridge between non-coding RNAs and coding messenger RNAs. CircRNAs are generated by a back-splicing mechanism during post-transcriptional processing and are abundantly expressed in eukaryotic cells. CircRNAs can act via the modulation of RNA transcription and protein production, and by the sponging of microRNAs (miRNAs). CircRNAs are now thought to be involved in many different biological and pathological processes. Some studies have suggested that the expression of host circRNAs is dysregulated in several types of virus-infected cells, compared to control cells. It is highly likely that viruses can use these molecules for their own purposes. In addition, some viral genes are able to produce viral circRNAs (VcircRNA) by a back-splicing mechanism. However, the viral genes that encode VcircRNAs, and their functions, are poorly studied. In this review, we highlight some new findings about the interaction of host circRNAs and viral infection. Moreover, the potential of VcircRNAs derived from the virus itself, to act as biomarkers and therapeutic targets is summarized.

show abstract

“…Non-coding RNAs (ncRNAs) comprise a huge part of human genome and are involved in various molecular pathways and processes [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. They are divided into two characteristic groups: house-keeping and regulatory molecules [ 49 ].…”

Section: Micrornasmentioning

confidence: 99%

MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy

et al. 2020

View full text Add to dashboard Cite

Molecular signaling pathways involved in cancer have been intensively studied due to their crucial role in cancer cell growth and dissemination. Among them, zinc finger E-box binding homeobox-1 (ZEB1) and -2 (ZEB2) are molecules that play vital roles in signaling pathways to ensure the survival of tumor cells, particularly through enhancing cell proliferation, promoting cell migration and invasion, and triggering drug resistance. Importantly, ZEB proteins are regulated by microRNAs (miRs). In this review, we demonstrate the impact that miRs have on cancer therapy, through their targeting of ZEB proteins. MiRs are able to act as onco-suppressor factors and inhibit the malignancy of tumor cells through ZEB1/2 down-regulation. This can lead to an inhibition of epithelial-mesenchymal transition (EMT) mechanism, therefore reducing metastasis. Additionally, miRs are able to inhibit ZEB1/2-mediated drug resistance and immunosuppression. Additionally, we explore the upstream modulators of miRs such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as these regulators can influence the inhibitory effect of miRs on ZEB proteins and cancer progression.

show abstract

Autophagy in cancers including brain tumors: role of MicroRNAs

Cited by 45 publications

References 244 publications

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma

Circular RNAs: New Epigenetic Signatures in Viral Infections

MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy

Contact Info

Product

Resources

About