Autophagy in filamentous fungi

Pollack, Judith K.; Harris, Steven D.; Marten, Mark R.

doi:10.1016/j.fgb.2008.10.010

Cited by 161 publications

(143 citation statements)

References 62 publications

Supporting

Mentioning

138

Contrasting

Unclassified

Order By: Relevance

“…S1e-h), a finding highlighting the complex cross-regulation between Th1 and Th17 responses that would also include an action on fungal cells. Host IL-17A sensing occurs via the TOR nutrient sensing pathway, a conserved mechanism among yeasts and filamentous fungi 33 that regulates autophagy 34 , cell growth and virulence 4,18,35 . Autophagy is an evolutionary conserved response to stress that has been linked to important protective roles in mammalian cells 36 .…”

Section: Discussionmentioning

confidence: 99%

Sensing of mammalian IL-17A regulates fungal adaptation and virulence

et al. 2012

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Sensing of mammalian IL-17A regulates fungal adaptation and virulence

et al. 2012

View full text Add to dashboard Cite

“…Although necrotic cell death is possible during any kind of stress, programmed cell death processes have also been observed during carbon starvation in several fungi (Emri et al, 2005;Cebollero & Gonzalez, 2006;Robson, 2006;Pollack et al, 2009;Sharon et al, 2009). In the case of A. nidulans, the appearance of apoptotic markers (membrane inversion, DNA fragmentation) was detected in late autolytic cultures, and macroautophagy has also been observed in both carbon-starved and rapamycin-treated cultures by Emri et al (2005) and Kim et al (2011), respectively.…”

Section: Programmed Cell Death During Carbon Starvationmentioning

confidence: 99%

“…Gene AN2876 is an orthologue of Saccharomyces cerevisiae atg22, encoding a vacuolar, autophagy-related amino acid permease (Yang et al, 2006). The genes AN5174 and AN7428 are orthologues of atg5 and atg7, respectively, and both are involved in the formation of autophagosomes in S. cerevisiae (Pollack et al, 2009). TipA is the orthologue of baker's yeast Tip41 (Fitzgibbon et al, 2005), which induces autophagy by inhibiting TOR signalling.…”

Section: Programmed Cell Death During Carbon Starvationmentioning

confidence: 99%

Transcriptome changes initiated by carbon starvation in Aspergillus nidulans

et al. 2013

View full text Add to dashboard Cite

Carbon starvation is a common stress for micro-organisms both in nature and in industry. The carbon starvation stress response (CSSR) involves the regulation of several important processes including programmed cell death and reproduction of fungi, secondary metabolite production and extracellular hydrolase formation. To gain insight into the physiological events of CSSR, DNA microarray analyses supplemented with real-time RT-PCR (rRT-PCR) experiments on 99 selected genes were performed. These data demonstrated that carbon starvation induced very complex changes in the transcriptome. Several genes contributing to protein synthesis were upregulated together with genes involved in the unfolded protein stress response. The balance between biosynthesis and degradation moved towards degradation in the case of cell wall, carbohydrate, lipid and nitrogen metabolism, which was accompanied by the production of several hydrolytic enzymes and the induction of macroautophagy. These processes provide the cultures with longterm survival by liberating nutrients through degradation of the cell constituents. The induced synthesis of secondary metabolites, antifungal enzymes and proteins as well as bacterial cell walldegrading enzymes demonstrated that carbon-starving fungi should have marked effects on the micro-organisms in their surroundings. Due to the increased production of extracellular and vacuolar enzymes during carbon starvation, the importance of the endoplasmic reticulum increased considerably.

show abstract

“…159 In Aspergillus oryzae autophagy appears to be involved in nutrient recycling during starvation; mutants of this species with deletions of the ATG1 or ATG8 gene were unable to undergo asexual development and acquire nutrients. 159,160 In a study of A. fumigatus, autophagy was required for aerial hyphae formation, conidial germination, hyphal foraging and growth under nutrient-deficient conditions; recent data have also suggested that autophagy contributes to metal ion homeostasis but the mechanism by which this occurs requires further investigation. 155,161 As for C. albicans, autophagy does not appear to be essential for virulence in mice with aspergillosis, 155,161 the reason for which remains to be defined.…”

Section: Autophagy Inhibitorsmentioning

confidence: 99%