Autophagy in stem cell aging

Revuelta, Miren; Matheu, Ander

doi:10.1111/acel.12655

Cited by 121 publications

(128 citation statements)

References 30 publications

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“…Over the past decade, researchers have made tremendous progress in under- standing stem cell aging and the molecular mechanisms underlying this process [34]. Previous studies have also confirmed the extrinsic ingredients, and transplantation trials have identified the intrinsic components that cause an age-dependent decline in the number and function of stem cells [130].…”

Section: Resultsmentioning

confidence: 99%

“…Autophagy is one of the hallmarks of aging [34]. It is a constitutive pathway associated with damage to organelles and protein aggregates through a decline in the number and function of stem cells [ It has been assumed that reactive oxygen species (ROS) may lead to a loss of differentiation [43] [44] [45].…”

Section: Impact Of Stem Cell Senescence In Aging and Diseasesmentioning

confidence: 99%

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Therapeutics of Stem Cell Treatment in Anti-Aging and Rejuvenation

Yeh¹,

Chan²

2018

SCD

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Aging populations are increasing the incidence of age-related diseases, resulting in problems at the individual and socioeconomic level. The need for effective strategies in regenerative medicine for the elderly is more important than ever. Previous studies have shown that the number and function of stem cells decline with age, thereby undermining endogenous repair processes. It has also been suggested that the aging-induced deterioration of stem cell function may play a key role in the pathophysiology of various aging-related diseases. Recent advances in our understanding of tissue regeneration and the development of methods aimed at inducing and differentiating pluripotent stem cells for cell replacement therapy which provides exciting opportunities for the treatment of degenerative diseases, such as those related to senility. In this review article, we examine several mechanisms that are believed to contribute to the aging-related dysfunction of stem cells associated with diseases of the immune system, cardiac tissue, neuronal system, articular cartilage, and skeletal muscle. We also discuss factors that affect the therapeutic potential of adult stem/progenitor cells as well as current trends in the treatment of these conditions using regenerative medicine.

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Section: Resultsmentioning

confidence: 99%

Section: Impact Of Stem Cell Senescence In Aging and Diseasesmentioning

confidence: 99%

Therapeutics of Stem Cell Treatment in Anti-Aging and Rejuvenation

Yeh¹,

Chan²

2018

SCD

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“…Altogether, autophagy is critical for protein and cellular homeostasis. The exact mechanisms underlying decreased autophagy with aging are unclear; however, it has been noted that autophagy is decreased in aging stem cell niches in particular, contributing to decreased regenerative capacity (Revuelta and Matheu 2017). There are many proteins that are involved in the autophagy pathway and among them are cathepsins.…”

Section: Discussionmentioning

confidence: 99%

Effects of nutraceutical intervention on serum proteins in aged rats

et al. 2020

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Aging is associated with many pathophysiological changes that could lead to the onset of degenerative disease. Some of the physiological changes that occur with aging include increased inflammation and decreased stem cell proliferation, leading to decreased capacity for tissue regeneration and loss of function. In previous studies, we and others have found nutraceutical intervention to ameliorate some of the deleterious effects associated with aging. In particular, we have previously shown that NT-020, a supplement composed of a proprietary blend of blueberries, green tea, vitamin D3, and carnosine, is able to rescue age-related cognitive deficits, impaired neurogenesis, and inflammation in rats. We have also previously demonstrated that stem cells cultured with old serum showed decreased proliferation; however, when stem cells were cultured in serum from old rats given a diet supplemented with NT-020, proliferation did not differ from that of cells cultured with serum from young rats. While it is clear that NT-020 is exerting a therapeutic, anti-aging effect, the mechanisms of action were yet to be fully elucidated.To that end, in the present study, we conducted a bioinformatics experiment to examine the rat proteome of serum from young and old control rats and young and old rats given a diet supplemented with NT-020. Serum from old rats showed an increase in some inflammatory and pro-aging factors while serum from old rats given a diet supplemented with NT-020 showed an increase in some anti-aging factors, most notably proteins associated with the complement system and autophagy. A number of immune functions that increase with age were shown to be downregulated with NT-020 treatment.

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“…However, other studies have shown that excessive autophagy could be related to neuronal death in cerebral ischemia (Fornai et al, ; Kabuta, Suzuki, & Wada, ; Shi et al, ). In addition, autophagy is also related to cellular aging, survival, and proliferation (Cianfanelli & Cecconi, ; Codogno & Meijer, ; Revuelta & Matheu, ). Wang et al concluded that curcumin strongly repressed MSC differentiation into astrocytes and immature neurons when they were in supportive medium, and inhibited the apoptosis and cell cycle in MSCs in the suspension.…”

Section: Molecular and Cellular Mechanisms Of Curcumin On Stem Cellsmentioning

confidence: 99%

“…However, other studies have shown that excessive autophagy could be related to neuronal death in cerebral ischemia (Fornai et al, 2008;Kabuta, Suzuki, & Wada, 2006;Shi et al, 2012). In addition, autophagy is also related to cellular aging, survival, and proliferation (Cianfanelli & Cecconi, 2015;Codogno & Meijer, 2005;Revuelta & Matheu, 2017).…”

Section: Ormond Et Al In a Study Used Stem Cells Alone Or In Combinamentioning

confidence: 99%

Stem Cell Therapy: Curcumin Does the Trick

Sharifi

Vahed

Ahmadian

et al. 2019

Phytotherapy Research

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Curcumin is a dietary polyphenol and a bioactive phytochemical agent that possesses anti‐inflammatory, antioxidant, anticancer, and chemopreventive properties. Some of the predominant activities of stem cells include regeneration of identical cells and the ability to maintain the proliferation and multipotentiality. However, these cells could be stimulated to differentiate into specific cell types. Curcumin protects some stem cells from toxicity and can stimulate proliferation and differentiation of stem cells. In the present review, we summarize the antioxidant, stemness activity, antiaging, and neuroprotective as well as wound healing and regenerative effects of curcumin.

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Autophagy in stem cell aging

Cited by 121 publications

References 30 publications

Therapeutics of Stem Cell Treatment in Anti-Aging and Rejuvenation

Therapeutics of Stem Cell Treatment in Anti-Aging and Rejuvenation

Effects of nutraceutical intervention on serum proteins in aged rats

Stem Cell Therapy: Curcumin Does the Trick

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