2014
DOI: 10.1158/1078-0432.ccr-13-2060
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Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer

Abstract: Purpose: Triple-negative breast cancers (TNBC) are defined by a lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (ERBB2/HER2). Although initially responsive to chemotherapy, most recurrent TNBCs develop resistance, resulting in disease progression. Autophagy is a lysosome-mediated degradation and recycling process that can function as an adaptive survival response during chemotherapy and contribute to chemoresistance. Our goal was to determi… Show more

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Cited by 132 publications
(115 citation statements)
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“…As a matter of fact, we and other several studies had confirmed the inference using induced resistant breast cancer cell model [18][19][20][21][22]. However, these studies did not directly investigate the relationship between autophagy and MDR, which is the main mechanism of anticancer drugs resistance.…”
Section: Discussionmentioning
confidence: 90%
“…As a matter of fact, we and other several studies had confirmed the inference using induced resistant breast cancer cell model [18][19][20][21][22]. However, these studies did not directly investigate the relationship between autophagy and MDR, which is the main mechanism of anticancer drugs resistance.…”
Section: Discussionmentioning
confidence: 90%
“…In fact, the role of autophagy in anticancer drug resistance has been confirmed by the results from several breast cancer cell lines (60)(61)(62)(63)(64)(65). Epirubicin can induce autophagy in MCF-7 cells, and the induced-autophagy protects the cells from death by blocking apoptosis (60).…”
Section: Autophagy In Cancer Therapeutic Responsiveness and Chemothermentioning
confidence: 87%
“…Furthermore, the inhibition of PTX and NVB induced-autophagy makes the cells more sensitive to these drugs, indicating the autophagy is also involved in MDR development (61). In addition, Chittaranjan et al (62) indicated that the blockage of epirubicin-induced autophagy augments the anticancer effects of epirubicin in triple-negative breast cancer MDA-MB-231 cells, derived resistant MDA-MB-231-R8 cells and SUM159PTR75 cells. These results suggest that autophagy facilitates epirubicin resistance development by blocking apoptosis.…”
Section: Autophagy In Cancer Therapeutic Responsiveness and Chemothermentioning
confidence: 99%
“…In the present study, we found that when combined with icaritin, EPI reached the same inhibitory effect on bladder cancer cells at a much lower dose compared to EPI treatment alone, suggesting that icaritin may serve as an adjuvant agent to boost EPI therapy. Recently, Chittaranjan et al found a similar result that EPI-resistant breast cancers cells treated with combination of EPI and autophagy inhibitor (hydroxychloroquine) markedly enhanced the inhibition of tumor growth comparing to those treated with EPI alone (36).…”
Section: Discussionmentioning
confidence: 76%
“…It is reported that EPI induces autophagy in human breast cancer MCF-7 cells, and EPI-induced autophagy protects MCF-7 cells from EPI-induced apoptosis (20). Also, EPI induces autophagy and serves as a pro-survival mechanism in triple negative breast cancers (TNBCs) (36). However, it has not been reported whether EPI may cause autophagy in bladder cancer.…”
Section: Discussionmentioning
confidence: 99%