Autophagy inhibition facilitates wound closure partially dependent on the YAP/IL‐33 signaling in a mouse model of skin wound healing

Gao, Yuan; Luo, Chengliang; Rui, Tongyu; Yao, Yi; Shen, Hengji; Gao, Cheng; Wang, Tao; Wang, Haochen; Chen, Xueshi; Zhang, Jiaxin; Li, Dongya; Xia, Chongjian; Li, Lili; Wang, Zufeng; Zhang, Mingyang; Chen, Xiping; Tao, Luyang

doi:10.1096/fj.202002623rrr

Cited by 11 publications

(9 citation statements)

References 55 publications

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“…217 Furthermore, the inhibition of YAP was shown to promote the expression of IL-33 and then lead to autophagy inhibition, which contributes to wound healing. 218 Collectively, embryonic development and adequate and efficient tissue regeneration require highly controlled and harmonious cell proliferation, as well as cell differentiation. Considerable efforts should be devoted to understanding the complex molecular mechanisms by which YAP/TAZ mediate these critical physiological functions.…”

Section: Critical Physiological Functions Of the Hippo Pathwaymentioning

confidence: 99%

The Hippo signalling pathway and its implications in human health and diseases

Lan

et al. 2022

Sig Transduct Target Ther

231

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As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in the regulation of numerous biological processes. Thus, substantial efforts have been made to understand the upstream signals that influence the activity of the Hippo pathway, as well as its physiological functions, such as cell proliferation and differentiation, organ growth, embryogenesis, and tissue regeneration/wound healing. However, dysregulation of the Hippo pathway can cause a variety of diseases, including cancer, eye diseases, cardiac diseases, pulmonary diseases, renal diseases, hepatic diseases, and immune dysfunction. Therefore, therapeutic strategies that target dysregulated Hippo components might be promising approaches for the treatment of a wide spectrum of diseases. Here, we review the key components and upstream signals of the Hippo pathway, as well as the critical physiological functions controlled by the Hippo pathway. Additionally, diseases associated with alterations in the Hippo pathway and potential therapies targeting Hippo components will be discussed.

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Section: Critical Physiological Functions Of the Hippo Pathwaymentioning

confidence: 99%

The Hippo signalling pathway and its implications in human health and diseases

Lan

et al. 2022

Sig Transduct Target Ther

231

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“…IL-33 has been shown to play an anti-in ammatory role depending on the target cell surface-speci c receptor ST2 in various brain injury models 10,29,30 , including TBI 31 . Speci cally, pharmacological inhibition or genetic deletion of IL-33 or ST2 has been shown to lead to microglial dystrophy, impairment of synaptic function, and behavioral abnormalities 32 .…”

Section: Discussionmentioning

confidence: 99%

“…The standard methods of immunohistochemical and double immuno uorescent staining used in this study have been previously described 30,49 . The brain tissue of mice was internally xed with 4% paraformaldehyde by cardiac perfusion.…”

Section: Immunohistochemical and Double Immuno Uorescent Stainingmentioning

confidence: 99%

Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury

Gao¹,

Wang²,

Cheng³

et al. 2023

Free Radical Biology and Medicine

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“…Nuclear localization of YAP was shown to be increased by treatment with calcipotriol, which induced EMT through the YAP/TGF‐β/Smad pathway to accelerate tissue repair 26 . YAP/interleukin 33 (IL‐33)‐mediated autophagy was identified as a potential pharmacologic target for accelerating wound healing 27 . The mechanism of YAP regulation observed in spiny mice ( Acomys cahirinus ) applied to human fibroblasts cultured in vitro was shown to prevent and rescue TGF‐β1–mediated myofibroblast differentiation, providing a basis for preventing scar formation during wound healing 28 .…”

Section: Relationship Between Yap and Skin Diseasesmentioning

confidence: 99%

Recent advances in the role of Yes‐associated protein in dermatosis

Jia

Liu

2023

Skin Research and Technology

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Background: Dermatosis is a general term for diseases of the skin and skin appendages including scleroderma, psoriasis, bullous disease, atopic dermatitis, basal cell carcinoma, squamous cell carcinoma, and melanoma. These diseases affect millions of individuals globally and are a serious public health concern. However, the pathogenesis of skin diseases is not fully understood, and treatments are not optimal. Yes-associated protein (YAP) is a transcriptional coactivator that plays a role in the regulation of gene transcription and signal transduction. Aims:To study the role of Yes-associated protein in skin diseases. Materials and Methods:The present review summarizes recent advances in our understanding of the role of YAP in skin diseases, current treatments that target YAP, and potential avenues for novel therapies.Results: Abnormal YAP expression has been implicated in occurrence and development of dermatosis. YAP regulates the cell homeostasis, proliferation, differentiation, apoptosis, angiopoiesis, and epithelial-to-mesenchymal transition, among other processes. As well as, it serves as a potential target in many biological processes for treating dermatosis. Conclusions:The effects of YAP on the skin are complex and require multidimensional investigational approaches. YAP functions as an oncoprotein that can promote the occurrence and development of cancer, but there is currently limited information on the therapeutic potential of YAP inhibition for cancer treatment. Additional studies are also needed to clarify the role of YAP in the development and maturation of dermal fibroblasts; skin barrier function, homeostasis, aging, and melanin production; and dermatosis.

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Autophagy inhibition facilitates wound closure partially dependent on the YAP/IL‐33 signaling in a mouse model of skin wound healing

Cited by 11 publications

References 55 publications

The Hippo signalling pathway and its implications in human health and diseases

The Hippo signalling pathway and its implications in human health and diseases

Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury

Recent advances in the role of Yes‐associated protein in dermatosis

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